产品
编 号:F450734
分子式:C16H17.5Cl0.5N9O5S3
分子量:529.79
产品类型
结构图
CAS No: 75738-58-8
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生物活性:
Cefmenoxime (SCE-1365) hydrochloride is a new semisynthetic cephalosporin antibiotic. Cefmenoxime has antibacterial activity against a wide variety of gram-positive and gram-negative bacteria.
体内研究:
Cefmenoxime (SCE-1365) hydrochloride (40 mg/kg; i.h.; daily, for 7 d; male Jcl:ICR mice) improves the survival rate of mice infected with lung bacteria.Animal Model:Male Jcl:ICR mice
Dosage:40 mg/kg
Administration:Subcutaneous injection; daily, for 7 days
Result:Inhibited mortality rate of animals was 60% at a dose of 40 mg/kg.
体外研究:
Cefmenoxime (SCE-1365) hydrochloride inhibits at least 90% of strains tested (MIC90) ranged from 0.06 to 8 μg/mL for the Enterobacteriaceae.Cefmenoxime (SCE-1365) hydrochloride inhibits MIC90 values for gram-positive cocci are 0.015 and ≤0.008 μg/mL for Streptococcus pneumoniae and Streptococcus pyogenes, respectively, and 2 μg/mL for S. aureus.Cefmenoxime (SCE-1365) hydrochloride against Haemophilus influenzae, Neisseria gonorrhoeae, and Neisseria meningitidis with MIC90 values ranging from ≤0.008 to 0.25 μg/mL.