产品
编 号：F005530
分子式：C33H35F3N6O3
分子量：620.66
分子式：C33H35F3N6O3
分子量：620.66
产品类型
规格
价格
是否有货
2mg
询价
询价
5mg
询价
询价
结构图
CAS No: 1012104-68-5
产品详情
生物活性：
IRAK inhibitor 4 is an interleukin-1 receptor associated kinase 4(IRAK4) inhibitor.
体内研究：
IRAK-4-/-?mice exhibit a greatly reduced survival rate following aerosol infection compared with IRAK-4+/+?or IRAK-4+/-?mice. IRAK-4-/- mice show increased bacterial burden in all organs at 15, 30, and 60 d postinfection. MCL1, but not BCL-xL, overrides the therapeutic effects of combinatorial IRAK1/4 inhibitor and ABT-737 therapy in vivo.
体外研究：
Lack of IRAK-4 impairs the production of proinflammatory mediators by macrophages and DCs in response to?M. bovis?and?M. tuberculosis. IRAK-4-/- cells stimulated with E. coli LPS display delayed activation kinetics of all signaling proteins analyzed, and exhibit dramatically reduced p65 phosphorylation. IRAK1/4 (20 μM) has an inhibitory effect on LPS mediated IL-6 production. IRAK1/4 inhibitor do not decrease p38 phosphorylation in AMs. Combination of IRAK1/4 and Rip2 inhibitors inhibits TLR2-mediated cytokine production in sarcoidosis PBMCs and AMs. IRAK4 is overexpressed and activated in T-ALL. IRAK4 mRNA level is elevated in T-ALL cells from patients compared with the levels detected in thymic T cells or T cells from peripheral blood.
IRAK inhibitor 4 is an interleukin-1 receptor associated kinase 4(IRAK4) inhibitor.
体内研究：
IRAK-4-/-?mice exhibit a greatly reduced survival rate following aerosol infection compared with IRAK-4+/+?or IRAK-4+/-?mice. IRAK-4-/- mice show increased bacterial burden in all organs at 15, 30, and 60 d postinfection. MCL1, but not BCL-xL, overrides the therapeutic effects of combinatorial IRAK1/4 inhibitor and ABT-737 therapy in vivo.
体外研究：
Lack of IRAK-4 impairs the production of proinflammatory mediators by macrophages and DCs in response to?M. bovis?and?M. tuberculosis. IRAK-4-/- cells stimulated with E. coli LPS display delayed activation kinetics of all signaling proteins analyzed, and exhibit dramatically reduced p65 phosphorylation. IRAK1/4 (20 μM) has an inhibitory effect on LPS mediated IL-6 production. IRAK1/4 inhibitor do not decrease p38 phosphorylation in AMs. Combination of IRAK1/4 and Rip2 inhibitors inhibits TLR2-mediated cytokine production in sarcoidosis PBMCs and AMs. IRAK4 is overexpressed and activated in T-ALL. IRAK4 mRNA level is elevated in T-ALL cells from patients compared with the levels detected in thymic T cells or T cells from peripheral blood.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备