产品
编 号:F450258
分子式:C12H19N3O4
分子量:269.3
产品类型
结构图
CAS No: 7561-51-5
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产品详情
生物活性:
H-Pro-Gly-Pro-OH is a collagen-derived matrikine that has classically been described as a neutrophil chemoattractant. H-Pro-Gly-Pro-OH is perfectly positioned to focus neutrophils on the site required and direct a localized repair response. H-Pro-Gly-Pro-OH activates the transcription of neurotrophins and their receptor genes after cerebral ischemia.
体内研究:
H-Pro-Gly-Pro-OH (37.5 μg/kg; i.p.) 在大鼠脑缺血后激活神经营养蛋白及其受体基因的转录。Animal Model:270-320 g, male Wistar rats (focal cerebral ischemia)
Dosage:37.5 μg/kg
Administration:I.p.; 15, 1 h, 4, 8, 24, 28, 32, 48, 52, and 56 h
Result:Enhanced the transcription of Bdnf and TrkC 3 h after pMCAO and Ngf, TrkB, TrkC, and TrkA 24 h after pMCAO.