产品
编 号：F450083
分子式：C4H6N2
分子量：82.1
分子式：C4H6N2
分子量：82.1
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
500mg
336
In-stock
1g
480
In-stock
5g
1920
In-stock
结构图
CAS No: 7554-65-6
产品详情
生物活性：
Fomepizole (4-Methylpyrazole) is a potent cytochrome P450 (CYP2E1) inhibitor. Fomepizole is a competitive inhibitor of the enzyme alcohol dehydrogenase. Fomepizole blocks further conversion of methanol and ethylene glycol to toxic metabolites. Fomepizole has the potential for an antidote for ethylene glycol or methanol poisoning.
体内研究：
Pretreatment with Fomepizole (4-Methylpyrazole; 25 mg/kg; IP) prolongs ethanol neurobehavioral toxicity in CD-1 miceAnimal Model:Male CD-1 mice weighing 18-25 g
Dosage:25 mg/kg
Administration:IP; single dose
Result:Decreased the dose of ethanol (1-5 g/kg; IP) at which 50% of the animals failed a particular outcome test (toxic dose 50; TD50).
Fomepizole (4-Methylpyrazole) is a potent cytochrome P450 (CYP2E1) inhibitor. Fomepizole is a competitive inhibitor of the enzyme alcohol dehydrogenase. Fomepizole blocks further conversion of methanol and ethylene glycol to toxic metabolites. Fomepizole has the potential for an antidote for ethylene glycol or methanol poisoning.
体内研究：
Pretreatment with Fomepizole (4-Methylpyrazole; 25 mg/kg; IP) prolongs ethanol neurobehavioral toxicity in CD-1 miceAnimal Model:Male CD-1 mice weighing 18-25 g
Dosage:25 mg/kg
Administration:IP; single dose
Result:Decreased the dose of ethanol (1-5 g/kg; IP) at which 50% of the animals failed a particular outcome test (toxic dose 50; TD50).
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