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编 号：F449933
分子式：C50H73N15O16S2
分子量：1204.34
分子式：C50H73N15O16S2
分子量：1204.34
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CAS No: 75499-44-4
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生物活性：
Argipressin (diacetate) (AVP (diacetate), also known as antidiuretic hormone (ADH)) is a 9 amino acid neuropeptide secreted by the posterior pituitary. Argipressin (diacetate) (AVP (diacetate)) can regulate the biological effects of fluid balance, osmolality and cardiovascular through three separate G-protein coupled receptors (GPCRs), namely Avpr1a (V1a), Avpr1b (V1b) and Avpr2 (V2). Argipressin (diacetate) (AVP (diacetate)) also have potentially important effects on centrally regulated metabolic processes.
体内研究：
Argipressin (diacetate) (AVP (diacetate)) (25 nmol/kg bw; intraperitoneal injection; once) significantly reduces overall AUC glucose values，but not increases insulin levels in mice.Animal Model:NIH Swiss mice (adult; male; 12-14weeks)
Dosage:25 nmol/kg bw
Administration:AVP (25 nmol/kg bw; intraperitoneal injection; once)
Result:Reduced (P<0.001) overall AUC glucose values，but not increased insulin levels in mice.
体外研究：
Argipressin (diacetate) (AVP (diacetate)) induces proliferation and prevented cytokine-induced apoptosis in rodent and human beta-cells.
Argipressin (diacetate) (AVP (diacetate), also known as antidiuretic hormone (ADH)) is a 9 amino acid neuropeptide secreted by the posterior pituitary. Argipressin (diacetate) (AVP (diacetate)) can regulate the biological effects of fluid balance, osmolality and cardiovascular through three separate G-protein coupled receptors (GPCRs), namely Avpr1a (V1a), Avpr1b (V1b) and Avpr2 (V2). Argipressin (diacetate) (AVP (diacetate)) also have potentially important effects on centrally regulated metabolic processes.
体内研究：
Argipressin (diacetate) (AVP (diacetate)) (25 nmol/kg bw; intraperitoneal injection; once) significantly reduces overall AUC glucose values，but not increases insulin levels in mice.Animal Model:NIH Swiss mice (adult; male; 12-14weeks)
Dosage:25 nmol/kg bw
Administration:AVP (25 nmol/kg bw; intraperitoneal injection; once)
Result:Reduced (P<0.001) overall AUC glucose values，but not increased insulin levels in mice.
体外研究：
Argipressin (diacetate) (AVP (diacetate)) induces proliferation and prevented cytokine-induced apoptosis in rodent and human beta-cells.
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