产品
编 号：F053290
分子式：C29H28N6O2
分子量：492.57
分子式：C29H28N6O2
分子量：492.57
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CAS No: 1169211-37-3
产品详情
生物活性：
CFI-400437 is an indolinone-derived, ATP-competitive kinase inhibitor with high selectivity for PLK4 (IC50 of 0.6 nM).
体内研究：
CFI-400437 (25 mg/kg, ip, once daily for 21 d) exhibits antitumor activity against MDA-MB-468 breast cancer mouse xenograft model.
体外研究：
CFI-400437 is a potent inhibitor of MCF-7, MDA-MB-468 and MDA-MB231 cell growth.CFI-400437 inhibits Aurora A, Aurora B, KDR and FLT-3 with IC50s of 0.37, 0.21, 0.48, and 0.18 μM, respectively, i.e. two orders of magnitude higher than its IC50 of 0.6 nM against PLK4.CFI-400437 inhibits both AURKB and AURKC at concentrations CFI-400437 相关抗体:
CFI-400437 is an indolinone-derived, ATP-competitive kinase inhibitor with high selectivity for PLK4 (IC50 of 0.6 nM).
体内研究：
CFI-400437 (25 mg/kg, ip, once daily for 21 d) exhibits antitumor activity against MDA-MB-468 breast cancer mouse xenograft model.
体外研究：
CFI-400437 is a potent inhibitor of MCF-7, MDA-MB-468 and MDA-MB231 cell growth.CFI-400437 inhibits Aurora A, Aurora B, KDR and FLT-3 with IC50s of 0.37, 0.21, 0.48, and 0.18 μM, respectively, i.e. two orders of magnitude higher than its IC50 of 0.6 nM against PLK4.CFI-400437 inhibits both AURKB and AURKC at concentrations CFI-400437 相关抗体:
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