产品
编 号：F449699
分子式：C25H29Cl2F3N2O4S
分子量：581.48
分子式：C25H29Cl2F3N2O4S
分子量：581.48
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
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1mg
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5mg
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10mg
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25mg
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50mg
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100mg
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结构图
CAS No: 754240-09-0
产品详情
生物活性：
EHT 1864 is an inhibitor of Rac family small GTPases. EHT 1864 directly binds and impairs the ability of this small GTPase to engage critical downstream effectors required for growth transformation. The Kd values are 40, 50, 60, and 230 nM for Rac1, Rac1b, Rac2 and Rac3, respectively.?EHT 1864 also potently inhibits other Rac-dependent transformation processes, Tiam1- and Ras-mediated growth transformation. EHT 1864 prevents Aβ?40 and Aβ?42 production in vivo. EHT 1864 dependently suppresses the release of migrasomes from podocytes induced by LPS, PAN, or HG.
体内研究：
EHT 1864 (口服给药) 表现出良好的耐受性、脑外显率和无遗传毒性。EHT 1864 (10 和 40 mg/kg/天；每天；15 天；腹膜内注射) 使豚鼠的脑 Aβ 40 降低 37%。
EHT 1864 is an inhibitor of Rac family small GTPases. EHT 1864 directly binds and impairs the ability of this small GTPase to engage critical downstream effectors required for growth transformation. The Kd values are 40, 50, 60, and 230 nM for Rac1, Rac1b, Rac2 and Rac3, respectively.?EHT 1864 also potently inhibits other Rac-dependent transformation processes, Tiam1- and Ras-mediated growth transformation. EHT 1864 prevents Aβ?40 and Aβ?42 production in vivo. EHT 1864 dependently suppresses the release of migrasomes from podocytes induced by LPS, PAN, or HG.
体内研究：
EHT 1864 (口服给药) 表现出良好的耐受性、脑外显率和无遗传毒性。EHT 1864 (10 和 40 mg/kg/天；每天；15 天；腹膜内注射) 使豚鼠的脑 Aβ 40 降低 37%。
产品资料
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