产品
编 号：F449462
分子式：C28H32N2O7
分子量：508.56
分子式：C28H32N2O7
分子量：508.56
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
100mg
1415
In-stock
500mg
询价
询价
结构图
CAS No: 753498-25-8
产品详情
生物活性：
Indacaterol maleate (QAB149) is an orally active ultra-long-acting β2 adrenergic receptor (ADRB2) agonist. Indacaterol maleate inhibits NF-κB activity in a β-arrestin2-dependent manner, preventing further lung damage and improving lung function in COPD (chronic obstructive pulmonary disorder). Indacaterol maleate can also be used in cardiovascular disease research.
体内研究：
Indacaterol maleate (0.3 mg/kg；口服；每天一次，持续 15 周) 在心力衰竭 (HF) 的心肌梗死 (MI) 大鼠模型中表现出正常化和逆转心脏重塑的活性。Animal Model:Male Wistar rats (225-250 g; myocardial infarction (MI) rat model of heart failure (HF)).
Dosage:0.3 mg/kg
Administration:In animal drinking water; sinle daily for 15 weeks
Result:Significantly reduced both mean arterial blood pressure and heart rate.Increased both systolic and diastolic LVID where in HF, and reversed the decreased ejection fraction (%) values.Significantly reduced the infarct size, and catecholamine values to basal levels.Significantly increased β1 mRNA expression and cardiac cAMP levels in respect to HF.
体外研究：
Indacaterol maleate (1，2.5，5，10 μM；12 h) 抑制人纤维肉瘤 HT1080 细胞中 TNF-α 诱导的 MMP-9 表达和活性。 Indacaterol maleate (10 μM；6 h) 通过降低 MMP-9 的表达和活性来抑制 TNF-α 诱导的人纤维肉瘤细胞的侵袭和迁移。 Indacaterol maleate (1，2.5，5，10 μM；2.5 h) 抑制 HT1080 细胞中 TNF-α 激活的 IKK/NF-кB 信号传导。
Indacaterol maleate (QAB149) is an orally active ultra-long-acting β2 adrenergic receptor (ADRB2) agonist. Indacaterol maleate inhibits NF-κB activity in a β-arrestin2-dependent manner, preventing further lung damage and improving lung function in COPD (chronic obstructive pulmonary disorder). Indacaterol maleate can also be used in cardiovascular disease research.
体内研究：
Indacaterol maleate (0.3 mg/kg；口服；每天一次，持续 15 周) 在心力衰竭 (HF) 的心肌梗死 (MI) 大鼠模型中表现出正常化和逆转心脏重塑的活性。Animal Model:Male Wistar rats (225-250 g; myocardial infarction (MI) rat model of heart failure (HF)).
Dosage:0.3 mg/kg
Administration:In animal drinking water; sinle daily for 15 weeks
Result:Significantly reduced both mean arterial blood pressure and heart rate.Increased both systolic and diastolic LVID where in HF, and reversed the decreased ejection fraction (%) values.Significantly reduced the infarct size, and catecholamine values to basal levels.Significantly increased β1 mRNA expression and cardiac cAMP levels in respect to HF.
体外研究：
Indacaterol maleate (1，2.5，5，10 μM；12 h) 抑制人纤维肉瘤 HT1080 细胞中 TNF-α 诱导的 MMP-9 表达和活性。 Indacaterol maleate (10 μM；6 h) 通过降低 MMP-9 的表达和活性来抑制 TNF-α 诱导的人纤维肉瘤细胞的侵袭和迁移。 Indacaterol maleate (1，2.5，5，10 μM；2.5 h) 抑制 HT1080 细胞中 TNF-α 激活的 IKK/NF-кB 信号传导。
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