产品
编 号：F449064
分子式：C21H24N4O6S
分子量：460.5
分子式：C21H24N4O6S
分子量：460.5
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CAS No: 752240-01-0
产品详情
生物活性：
MK-0941 free base is an orally active glucokinase activator, with EC50s of 240 and 65 nM for recombinant human glucokinase in the presence of 2.5 and 10 mM glucose, respectively. MK-0941 free base exhibits strong glucose-lowering activity and is a potential therapeutic agent for treatment of type 2 diabetes.
体内研究：
MK-0941 free base (3 or 10 mg/kg, sing oral dose) treatment reduced blood glucose significantly in db/db diabetic mouse.Animal Model:Male db/db and db/+ (lean) mice (9-10 weeks of age, weighing 43-45 g) .
Dosage:3 or 10 mg/kg.
Administration:Oral gavage, single dose.
Result:Resulted in significant reduction in blood glucose. These two doses lowered blood glucose similarly at 1 h after dosing, suggesting that saturation of effect was approached.
MK-0941 free base is an orally active glucokinase activator, with EC50s of 240 and 65 nM for recombinant human glucokinase in the presence of 2.5 and 10 mM glucose, respectively. MK-0941 free base exhibits strong glucose-lowering activity and is a potential therapeutic agent for treatment of type 2 diabetes.
体内研究：
MK-0941 free base (3 or 10 mg/kg, sing oral dose) treatment reduced blood glucose significantly in db/db diabetic mouse.Animal Model:Male db/db and db/+ (lean) mice (9-10 weeks of age, weighing 43-45 g) .
Dosage:3 or 10 mg/kg.
Administration:Oral gavage, single dose.
Result:Resulted in significant reduction in blood glucose. These two doses lowered blood glucose similarly at 1 h after dosing, suggesting that saturation of effect was approached.
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