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编 号：F447908
分子式：C23H28O3
分子量：352.47
分子式：C23H28O3
分子量：352.47
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CAS No: 74915-64-3
产品详情
生物活性：
RU28362 is a potent and selective glucocorticoid agonist. RU28362 increases the Bnip3 mRNA levels in neurons. RU28362 inhibits adrenocorticotrophic hormone (ACTH) and corticosterone secretion. RU28362 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
体内研究：
RU28362 (150 μg/kg；腹腔注射) 可抑制促肾上腺皮质激素 (ACTH) 和皮质酮的分泌，并选择性抑制应激诱导的垂体前叶 POMC hnRNA 增加。Animal Model:250-350 g, adult male Sprague-Dawley rats
Dosage:150 μg/kg
Administration:I.p.; 60 min before exposure to a 15-min period of restraint stress
Result:Inhibited adrenocorticotrophic hormone (ACTH) and corticosterone secretion and selectively suppressed the stress-induced increase in POMC hnRNA in the anterior pituitary gland.
体外研究：
RU28362 (0.1、1、5、10 nM; 72 小时) 会以剂量依赖性方式增加神经元中的 Bnip3 mRNA 水平。
RU28362 is a potent and selective glucocorticoid agonist. RU28362 increases the Bnip3 mRNA levels in neurons. RU28362 inhibits adrenocorticotrophic hormone (ACTH) and corticosterone secretion. RU28362 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
体内研究：
RU28362 (150 μg/kg；腹腔注射) 可抑制促肾上腺皮质激素 (ACTH) 和皮质酮的分泌，并选择性抑制应激诱导的垂体前叶 POMC hnRNA 增加。Animal Model:250-350 g, adult male Sprague-Dawley rats
Dosage:150 μg/kg
Administration:I.p.; 60 min before exposure to a 15-min period of restraint stress
Result:Inhibited adrenocorticotrophic hormone (ACTH) and corticosterone secretion and selectively suppressed the stress-induced increase in POMC hnRNA in the anterior pituitary gland.
体外研究：
RU28362 (0.1、1、5、10 nM; 72 小时) 会以剂量依赖性方式增加神经元中的 Bnip3 mRNA 水平。
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