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编 号：F447828
分子式：C11H13N3O
分子量：203.24
分子式：C11H13N3O
分子量：203.24
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CAS No: 74885-09-9
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生物活性：
5-Carboxamidotryptamine (5-CT) is a 5-HT1A, 5-HT1B, 5-HT1D, 5-HT5A, 5-HT7 receptor agonist. 5-Carboxamidotryptamine has a Ki value of 4.6 nM for cloned human 5-HT5A receptor. 5-Carboxamidotryptamine causes a dose-dependent reduction in rectal temperature of mice.
体内研究：
5-Carboxamidotryptamine (0.03-3 mg/kg i.p. and 0.125-5 μg i.c.v.) causes a dose-dependent reduction in rectal temperature of mice.5-Carboxamidotryptamine (0.1-1 mg/kg; i.p.) reduces rectal temperature in wild type mice but not 5-HT7 receptor knockout mice.5-Carboxamidotryptamine (0.0 1-1 μg/kg; i.v.) causes consistent, dose-related decreases in diastolic blood pressure and carotid arterial vascular resistance and increases in heart rate of cats. In contrast, 5-HT (1-100 μg/kg; i.v.) causes tachycardia but variable and complex effects on diastolic blood pressure and carotid arterial vascular resistance.5-Carboxamidotryptamine does not cause bronchoconstriction in cats. In contrast, 5-HT causes dose-related bronchoconstriction.Animal Model:Male Swiss Webster mice (20-25 g)
Dosage:0.03-3 mg/kg (i.p.) and 0.125-5 μg (i.c.v.)
Administration:i.p. and i.c.v.
Result:Caused dose-dependent reduction in rectal temperature.
Animal Model:5-HT7 receptor knockout mice (background=50% 129SvEv/50% C57Bl/6J)
Dosage:0.1-1 mg/kg
Administration:i.p. and i.c.v.
Result:Reduced rectal temperature in wild type but not 5-HT7 receptor knockout mice.
5-Carboxamidotryptamine (5-CT) is a 5-HT1A, 5-HT1B, 5-HT1D, 5-HT5A, 5-HT7 receptor agonist. 5-Carboxamidotryptamine has a Ki value of 4.6 nM for cloned human 5-HT5A receptor. 5-Carboxamidotryptamine causes a dose-dependent reduction in rectal temperature of mice.
体内研究：
5-Carboxamidotryptamine (0.03-3 mg/kg i.p. and 0.125-5 μg i.c.v.) causes a dose-dependent reduction in rectal temperature of mice.5-Carboxamidotryptamine (0.1-1 mg/kg; i.p.) reduces rectal temperature in wild type mice but not 5-HT7 receptor knockout mice.5-Carboxamidotryptamine (0.0 1-1 μg/kg; i.v.) causes consistent, dose-related decreases in diastolic blood pressure and carotid arterial vascular resistance and increases in heart rate of cats. In contrast, 5-HT (1-100 μg/kg; i.v.) causes tachycardia but variable and complex effects on diastolic blood pressure and carotid arterial vascular resistance.5-Carboxamidotryptamine does not cause bronchoconstriction in cats. In contrast, 5-HT causes dose-related bronchoconstriction.Animal Model:Male Swiss Webster mice (20-25 g)
Dosage:0.03-3 mg/kg (i.p.) and 0.125-5 μg (i.c.v.)
Administration:i.p. and i.c.v.
Result:Caused dose-dependent reduction in rectal temperature.
Animal Model:5-HT7 receptor knockout mice (background=50% 129SvEv/50% C57Bl/6J)
Dosage:0.1-1 mg/kg
Administration:i.p. and i.c.v.
Result:Reduced rectal temperature in wild type but not 5-HT7 receptor knockout mice.
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