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编 号：F447657
分子式：C29H32ClN5O2
分子量：518.05
分子式：C29H32ClN5O2
分子量：518.05
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CAS No: 74847-35-1
产品详情
生物活性：
Pyronaridine is an orally active Mannich base anti-malarial agent. Pyronaridine is active against P. falciparum and Echinococcus granulosus infection.
体内研究：
Pyronaridine (57 mg/kg, oral administration, q.d. for 30 days) reduces the parasitic burden in the Echinococcus granulosus-infected mice.Pyronaridine (57 mg/kg, intraperitoneal injection, q.d. for 3 days) reduces the parasitic burden in secondarily infected (cysts) mice.Pyronaridine (57 mg/kg, intraperitoneal injection, for a single dose) exhibits a higher exposure in the liver than in the plasma in male ICR mice.Animal Model:Echinococcus granulosus-infected mice model
Dosage:57 mg/kg
Administration:Oral administration, q.d. for 30 days
Result:Reduced 42.4% of parasite wet weight and killed 90.7% of secondary infection (cysts) of E. granulosus ss.
体外研究：
Pyronaridine (24 h) shows anti-P. falciparum activity with an IC50 value of 1.53-3.94 nM.
Pyronaridine is an orally active Mannich base anti-malarial agent. Pyronaridine is active against P. falciparum and Echinococcus granulosus infection.
体内研究：
Pyronaridine (57 mg/kg, oral administration, q.d. for 30 days) reduces the parasitic burden in the Echinococcus granulosus-infected mice.Pyronaridine (57 mg/kg, intraperitoneal injection, q.d. for 3 days) reduces the parasitic burden in secondarily infected (cysts) mice.Pyronaridine (57 mg/kg, intraperitoneal injection, for a single dose) exhibits a higher exposure in the liver than in the plasma in male ICR mice.Animal Model:Echinococcus granulosus-infected mice model
Dosage:57 mg/kg
Administration:Oral administration, q.d. for 30 days
Result:Reduced 42.4% of parasite wet weight and killed 90.7% of secondary infection (cysts) of E. granulosus ss.
体外研究：
Pyronaridine (24 h) shows anti-P. falciparum activity with an IC50 value of 1.53-3.94 nM.
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