产品
编 号：F447317
分子式：C12H12Cl2N2O
分子量：271.14
分子式：C12H12Cl2N2O
分子量：271.14
产品类型
规格
价格
是否有货
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
50mg
询价
询价
结构图
CAS No: 747408-78-2
产品详情
生物活性：
PBT 1033 (PBT 2) is an orally active copper/zinc ionophore. PBT 1033 restores cognition in mouse models of Alzheimer's disease (AD). PB 1033 also has antibacterial activity against Gram-positive bacteria.
体内研究：
PBT 1033 (30 mg/kg/d, p.o., 11 days) restores biochemical substrates of learning/memory in a mouse model of alzheimer's disease.Animal Model:Female Tg2576 mice
Dosage:30 mg/kg/d
Administration:Oral administration, 11 days
Result:Increased hippocampal apical spine density, basal spine density.
体外研究：
PB 1033 displays antibacterial activity against S. uberis, with a MIC value of 14.5?μM.PBT2 (1, 3 and 7.5 μM, 6 h) protects neurons against glutamate-induced excitotoxicity.PBT2 (10 μM, 1 or 6 h) reduces NMDAR-mediated Ca2+ flux in mouse cortical neurons.PBT2 (0-10 μM, 1 h) increases GSK3α/β phosphorylation in SH-SY5Y cells.PBT2 (20 μM, 1 h) prevents the formation of Zn-induced protease resistant Aβ aggregates.
PBT 1033 (PBT 2) is an orally active copper/zinc ionophore. PBT 1033 restores cognition in mouse models of Alzheimer's disease (AD). PB 1033 also has antibacterial activity against Gram-positive bacteria.
体内研究：
PBT 1033 (30 mg/kg/d, p.o., 11 days) restores biochemical substrates of learning/memory in a mouse model of alzheimer's disease.Animal Model:Female Tg2576 mice
Dosage:30 mg/kg/d
Administration:Oral administration, 11 days
Result:Increased hippocampal apical spine density, basal spine density.
体外研究：
PB 1033 displays antibacterial activity against S. uberis, with a MIC value of 14.5?μM.PBT2 (1, 3 and 7.5 μM, 6 h) protects neurons against glutamate-induced excitotoxicity.PBT2 (10 μM, 1 or 6 h) reduces NMDAR-mediated Ca2+ flux in mouse cortical neurons.PBT2 (0-10 μM, 1 h) increases GSK3α/β phosphorylation in SH-SY5Y cells.PBT2 (20 μM, 1 h) prevents the formation of Zn-induced protease resistant Aβ aggregates.
产品资料
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