产品
编 号：F447205
分子式：C17H14O3S
分子量：298.36
分子式：C17H14O3S
分子量：298.36
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
400
In-stock
10mg
640
In-stock
50mg
1200
In-stock
100mg
1760
In-stock
结构图
CAS No: 74711-43-6
产品详情
生物活性：
Zaltoprofen (CN100), a non-steroidal anti-inflammatory drug (NSAID), is a preferential and orally active COX-2 inhibitor, with IC50s of 1.3 and 0.34 μM for COX-1 and COX-2, respectively. Zaltoprofen exhibits powerful anti-inflammatory effects as well as an analgesic action on inflammatory pain.
体内研究：
Zaltoprofen (5-20 mg/kg; a single p.o.) inhibits bradykinin-induced nociceptive responses in rats.Zaltoprofen (3-30 mg/kg; a single p.o.) inhibits the acetic acid-induced writhing response of mice in a dose-dependent manner.Animal Model:Eight-week-old male Wistar rats were injected Bradykinin every 15 min
Dosage:5, 10, 20 mg/kg
Administration:A single p.o.
Result:Inhibited bradykinin-induced nociceptive responses, with an ED50 of 9.7 mg/kg.The duration of analgesic effect was 60-90 min.
体外研究：
Zaltoprofen (0.1-10 μM; 15 min) inhibits thromboxane B2 production in human platelets in a dose-dependent manner.Zaltoprofen (0.01-1 μM; 30 min) inhibits prostaglandin E2 production by interleukin-1β-stimulated synovial cells.Zaltoprofen (0.1-1 μM; 5 min) inhibits the bradykinin-induced increase of [Ca2+]i in DRG cells.
Zaltoprofen (CN100), a non-steroidal anti-inflammatory drug (NSAID), is a preferential and orally active COX-2 inhibitor, with IC50s of 1.3 and 0.34 μM for COX-1 and COX-2, respectively. Zaltoprofen exhibits powerful anti-inflammatory effects as well as an analgesic action on inflammatory pain.
体内研究：
Zaltoprofen (5-20 mg/kg; a single p.o.) inhibits bradykinin-induced nociceptive responses in rats.Zaltoprofen (3-30 mg/kg; a single p.o.) inhibits the acetic acid-induced writhing response of mice in a dose-dependent manner.Animal Model:Eight-week-old male Wistar rats were injected Bradykinin every 15 min
Dosage:5, 10, 20 mg/kg
Administration:A single p.o.
Result:Inhibited bradykinin-induced nociceptive responses, with an ED50 of 9.7 mg/kg.The duration of analgesic effect was 60-90 min.
体外研究：
Zaltoprofen (0.1-10 μM; 15 min) inhibits thromboxane B2 production in human platelets in a dose-dependent manner.Zaltoprofen (0.01-1 μM; 30 min) inhibits prostaglandin E2 production by interleukin-1β-stimulated synovial cells.Zaltoprofen (0.1-1 μM; 5 min) inhibits the bradykinin-induced increase of [Ca2+]i in DRG cells.
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