产品
编 号：F446729
分子式：C16H13NO2
分子量：251.28
分子式：C16H13NO2
分子量：251.28
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
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10mg
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50mg
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100mg
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结构图
CAS No: 74588-78-6
产品详情
生物活性：
D-64131 is an orally active tubulin inhibitor, with an IC50 of 0.53 μM for tubulin polymerization. D-64131 has antimitotic activity. D-64131 can be used for cancer research.
体内研究：
D-64131 (200-400 mg/kg; p.o.; daily; days 1-5, 8-9, and 15-18) significantly inhibits tumor growth in the human amelanoic melanoma MEXF 989 tumor xenograft mice model.D-64131 has oral bioavailability and is well tolerated at efficacious doses.Animal Model:Outbred nude mice (6-8 weeks),human amelanoic melanoma MEXF 989 tumor xenograft model
Dosage:200 mg/kg, 400 mg/kg
Administration:Oral administration, daily, on days 1-5, 8-9, and 15-18 after xenograft
Result:Resulted in significant tumor growth inhibition during treatment.
体外研究：
D-64131 is antimitotic by binding to β-tubulin, thereby destabilizing microtubules and arresting mitotic cells in the M-phase.D-64131 inhibits the proliferation of tumor cells from 12 of 14 different organs and tissues with mean IC50s of 62 nM.D-64131 is cytotoxic toward MDR/MRP tumor cell lines.D-64131 suppresses U373 proliferation and cell cycle with IC50s of 74 nM and 62.7nM, respectively.
D-64131 is an orally active tubulin inhibitor, with an IC50 of 0.53 μM for tubulin polymerization. D-64131 has antimitotic activity. D-64131 can be used for cancer research.
体内研究：
D-64131 (200-400 mg/kg; p.o.; daily; days 1-5, 8-9, and 15-18) significantly inhibits tumor growth in the human amelanoic melanoma MEXF 989 tumor xenograft mice model.D-64131 has oral bioavailability and is well tolerated at efficacious doses.Animal Model:Outbred nude mice (6-8 weeks),human amelanoic melanoma MEXF 989 tumor xenograft model
Dosage:200 mg/kg, 400 mg/kg
Administration:Oral administration, daily, on days 1-5, 8-9, and 15-18 after xenograft
Result:Resulted in significant tumor growth inhibition during treatment.
体外研究：
D-64131 is antimitotic by binding to β-tubulin, thereby destabilizing microtubules and arresting mitotic cells in the M-phase.D-64131 inhibits the proliferation of tumor cells from 12 of 14 different organs and tissues with mean IC50s of 62 nM.D-64131 is cytotoxic toward MDR/MRP tumor cell lines.D-64131 suppresses U373 proliferation and cell cycle with IC50s of 74 nM and 62.7nM, respectively.
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