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编 号：F446577
分子式：C19H25N3O2S2
分子量：391.55
分子式：C19H25N3O2S2
分子量：391.55
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CAS No: 7456-24-8
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生物活性：
Dimethothiazine (Dimetotiazine; Fonazine) is an orally active tricyclic anti-histamine, anti-5-HT agent with a high activity against decerebrate rigidity, a little sedative activity and little soporific action. Dimethothiazine can reduce or abolish the effects of both static and dynamic fusimotor activity on the muscle spindle in decerebrate cat. Dimethothiazine can be used to research hemicrania and spasticity.
体内研究：
Dimethothiazine (0.5-16 mg/kg; i.v.; single dosage) reduces decerebrate rigidity in cats.Animal Model:Cats (decerebrate model; the carotid arteries were clamped and the mid-brain sectioned approximately between the colliculae)
Dosage:0.5, 1, 2, 4, 8 and 16 mg/kg
Administration:i.v.; single dosage
Result:Reduced the discharge frequency of primary and secondary endings at 1-4 mg/kg.Reduced the sensitivity of the muscle spindle to stretch in preparations with intact ventral roots.Reduced the activity of the dynamic fusimotor fibres.
Dimethothiazine (Dimetotiazine; Fonazine) is an orally active tricyclic anti-histamine, anti-5-HT agent with a high activity against decerebrate rigidity, a little sedative activity and little soporific action. Dimethothiazine can reduce or abolish the effects of both static and dynamic fusimotor activity on the muscle spindle in decerebrate cat. Dimethothiazine can be used to research hemicrania and spasticity.
体内研究：
Dimethothiazine (0.5-16 mg/kg; i.v.; single dosage) reduces decerebrate rigidity in cats.Animal Model:Cats (decerebrate model; the carotid arteries were clamped and the mid-brain sectioned approximately between the colliculae)
Dosage:0.5, 1, 2, 4, 8 and 16 mg/kg
Administration:i.v.; single dosage
Result:Reduced the discharge frequency of primary and secondary endings at 1-4 mg/kg.Reduced the sensitivity of the muscle spindle to stretch in preparations with intact ventral roots.Reduced the activity of the dynamic fusimotor fibres.
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