产品
编 号：F446367
分子式：C36H59NO6
分子量：601.86
分子式：C36H59NO6
分子量：601.86
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 745020-66-0
产品详情
生物活性：
NVX-207, a Betulinic acid-derived anti-cancer compound, shows anti-tumor activity (mean IC50=3.5 μM) against various human and canine cell lines. NVX-207-induced apoptosis is associated with activation of the intrinsic apoptotic pathway via cleavage of caspases -9, -3, -7 and of PARP.
体内研究：
Intravenous application of NVX-207 in mice is well tolerated.
体外研究：
NVX-207 induces cell death via apoptosis. NVX-207 has a high cytotoxicity with IC50 values ranging from 7.6-8.5 μM, in the three analyzed malignant glioma cell lines. NVX-207 leads to PARP cleavage and to a decrease in Survivin expression levels under normoxic and hypoxic conditions. NVX-207 (20 μM) causes a significantly high rate of necrosis of glioma cell lines.
NVX-207, a Betulinic acid-derived anti-cancer compound, shows anti-tumor activity (mean IC50=3.5 μM) against various human and canine cell lines. NVX-207-induced apoptosis is associated with activation of the intrinsic apoptotic pathway via cleavage of caspases -9, -3, -7 and of PARP.
体内研究：
Intravenous application of NVX-207 in mice is well tolerated.
体外研究：
NVX-207 induces cell death via apoptosis. NVX-207 has a high cytotoxicity with IC50 values ranging from 7.6-8.5 μM, in the three analyzed malignant glioma cell lines. NVX-207 leads to PARP cleavage and to a decrease in Survivin expression levels under normoxic and hypoxic conditions. NVX-207 (20 μM) causes a significantly high rate of necrosis of glioma cell lines.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备