产品
编 号：F444713
分子式：C20H23BrClNO2
分子量：424.76
分子式：C20H23BrClNO2
分子量：424.76
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CAS No: 74115-10-9
产品详情
生物活性：
SKF83822 hydrobromide is a potent dopamine D1 receptor agonist. SKF83822 hydrobromide activates Gs/olf/adenylyl cyclase (AC)-coupled D1 receptors, but not phospholipase C (PLC)-coupled D1-like receptors.
体内研究：
SKF83822 activates dopamine D1 receptors coupled to Gαs/olf and downstream cyclase activity. SKF83822 produces a locomotor response in both rodent and non-human primate models without affecting stereotypy, intense grooming, or dyskinesia. An acute injection of SKF83822 (0.4 mg/kg; i.p.) induced a greater than threefold increase in locomotor activity relative to the baseline period for each genotype.Animal Model:Gαq knockout mice
Dosage:0.4 mg/kg
Administration:
Result:There was a significant increase in locomotor activity in each genotype.
体外研究：
SKF83822 (1 μM) increases DARPP-32 phosphorylation in Neostriatal slices. Treatment with SKF83822 for 5 min stimulates DARPP-32 Thr34 phosphorylation maximally at a concentration of 100 μM with a half maximal effect at ～1 μM. SKF83822 (1?μM) does not affect the phosphorylation of DARPP-32 at Thr75, Ser97 or Ser130.
SKF83822 hydrobromide is a potent dopamine D1 receptor agonist. SKF83822 hydrobromide activates Gs/olf/adenylyl cyclase (AC)-coupled D1 receptors, but not phospholipase C (PLC)-coupled D1-like receptors.
体内研究：
SKF83822 activates dopamine D1 receptors coupled to Gαs/olf and downstream cyclase activity. SKF83822 produces a locomotor response in both rodent and non-human primate models without affecting stereotypy, intense grooming, or dyskinesia. An acute injection of SKF83822 (0.4 mg/kg; i.p.) induced a greater than threefold increase in locomotor activity relative to the baseline period for each genotype.Animal Model:Gαq knockout mice
Dosage:0.4 mg/kg
Administration:
Result:There was a significant increase in locomotor activity in each genotype.
体外研究：
SKF83822 (1 μM) increases DARPP-32 phosphorylation in Neostriatal slices. Treatment with SKF83822 for 5 min stimulates DARPP-32 Thr34 phosphorylation maximally at a concentration of 100 μM with a half maximal effect at ～1 μM. SKF83822 (1?μM) does not affect the phosphorylation of DARPP-32 at Thr75, Ser97 or Ser130.
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