产品
编 号：F444711
分子式：C19H21BrClNO2
分子量：410.73
分子式：C19H21BrClNO2
分子量：410.73
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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1mg
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5mg
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10mg
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25mg
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50mg
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结构图
CAS No: 74115-01-8
产品详情
生物活性：
SKF-82958 ((±)-SKF 82958) hydrobromide is a dopamine D1 receptor full agonist (K0.5=4 nM), displays selective for D1 over D2 receptors (K0.5=73 nM). SKF-82958 hydrobromide induces dopamine D1 receptor-dependent adenylate cyclase activity in rat striatal membranes (EC50=491 nM).
体内研究：
SKF-82958 ((±)-SKF 82958) hydrobromide (0.003-0.1 mg/kg；ip) 导致对 SKF-82958 hydrobromide 适当杠杆的反应呈剂量依赖性增加，在接受 SKF-82958 hydrobromide 氢溴酸盐训练后完全替代剂量 0.03 mg/kg。增加 SKF-82958 hydrobromide 氢溴酸盐的剂量也会显著降低反应率。 SKF-82958 hydrobromide 氢溴酸盐 (0.5-2.0 mg/kg；ip) 显著抑制毛果芸香碱-诱发下颌运动。Animal Model:Male Sprague-Dawley rats
Dosage:0.5-2.0 mg/kg
Administration:I.p
Result:Significantly reduced the number of tremulous jaw movements induced by 4.0 mg/kg pilocarpine.
SKF-82958 ((±)-SKF 82958) hydrobromide is a dopamine D1 receptor full agonist (K0.5=4 nM), displays selective for D1 over D2 receptors (K0.5=73 nM). SKF-82958 hydrobromide induces dopamine D1 receptor-dependent adenylate cyclase activity in rat striatal membranes (EC50=491 nM).
体内研究：
SKF-82958 ((±)-SKF 82958) hydrobromide (0.003-0.1 mg/kg；ip) 导致对 SKF-82958 hydrobromide 适当杠杆的反应呈剂量依赖性增加，在接受 SKF-82958 hydrobromide 氢溴酸盐训练后完全替代剂量 0.03 mg/kg。增加 SKF-82958 hydrobromide 氢溴酸盐的剂量也会显著降低反应率。 SKF-82958 hydrobromide 氢溴酸盐 (0.5-2.0 mg/kg；ip) 显著抑制毛果芸香碱-诱发下颌运动。Animal Model:Male Sprague-Dawley rats
Dosage:0.5-2.0 mg/kg
Administration:I.p
Result:Significantly reduced the number of tremulous jaw movements induced by 4.0 mg/kg pilocarpine.
产品资料
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