产品
编 号：F005482
分子式：C13H9Cl3N2O
分子量：315.58
分子式：C13H9Cl3N2O
分子量：315.58
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
500mg
200
In-stock
1g
320
In-stock
结构图
CAS No: 101-20-2
产品详情
生物活性：
Triclocarban (3,4,4′-Trichlorocarbanilide), a broad spectrum antibacterial compound, is widely used in a broad range of applications such as the production of soaps, skin creams, toothpastes and deodorants. Triclocarban is a potential endocrine-disrupting chemical with the capacity to modulate androgen and estrogen activities as well as other hormone-mediated biological processes.
体内研究：
Triclocarban is absorbed significantly from soap used during showering in human subjects and that its Cmax in their whole blood ranges from 23 nM to 530 nM. Gestational triclocarban exposure does not affect the ability of dams to carry offspring to term but triclocarban exposure during lactation has adverse consequences on the survival of offspring.
体外研究：
Triclocarban (300 nM) potentiates the cytotoxicity of 300 μM H2O2 in rat thymocytes.Triclocarban (300 nM) does not increase the population of death cells, it facilitates the process of cell death induced by H2O2, resulting in further increase in the population of dead cells. Triclocarban exertes estrogenic activities by inducing luciferase activities in an ER reporter gene assay, promoting the proliferation of the MCF-7 cells, up-regulating the expression of pS2 and down-regulating ERα expression at both the mRNA and protein levels in the MCF-7 cells.
Triclocarban (3,4,4′-Trichlorocarbanilide), a broad spectrum antibacterial compound, is widely used in a broad range of applications such as the production of soaps, skin creams, toothpastes and deodorants. Triclocarban is a potential endocrine-disrupting chemical with the capacity to modulate androgen and estrogen activities as well as other hormone-mediated biological processes.
体内研究：
Triclocarban is absorbed significantly from soap used during showering in human subjects and that its Cmax in their whole blood ranges from 23 nM to 530 nM. Gestational triclocarban exposure does not affect the ability of dams to carry offspring to term but triclocarban exposure during lactation has adverse consequences on the survival of offspring.
体外研究：
Triclocarban (300 nM) potentiates the cytotoxicity of 300 μM H2O2 in rat thymocytes.Triclocarban (300 nM) does not increase the population of death cells, it facilitates the process of cell death induced by H2O2, resulting in further increase in the population of dead cells. Triclocarban exertes estrogenic activities by inducing luciferase activities in an ER reporter gene assay, promoting the proliferation of the MCF-7 cells, up-regulating the expression of pS2 and down-regulating ERα expression at both the mRNA and protein levels in the MCF-7 cells.
产品资料
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