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编 号:F442923
分子式:C12H16N2S
分子量:220.33
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Xylazine (BAY 1470) is a strong α2-adrenergic agonist whose effects are mediated via stimulation of central α2-receptors. Xylazine hydrochloride is used as a sedative, analgesic and muscle relaxant in veterinary medicine.

体内研究:
Xylazine (5.2 mg/kg; intraperitoneal injection; for 10-60 minutes; male Sprague-Dawley rats) administration alters mRNA expression and protein phosphorylation levels of AMPK signaling molecules, suggesting that the LKB1-AMPK pathway plays a role in the sedative and tranquilizing effects in the CNS caused by Xylazine treatment.Animal Model:Male Sprague-Dawley rats (160-180 g)
Dosage:5.2 mg/kg
Administration:Intraperitoneal injection; for 10 minutes, 20 minutes, 40 minutesor 60 minutes
Result:Increased in AMPK activity in the cerebral cortex, hippocampus, thalamus and cerebellum. Phosphorylated LKB1 and AMPKα protein levels were decreased.
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