产品
编 号:F442005
分子式:C14H13N3O2S
分子量:287.34
产品类型
结构图
CAS No: 73384-60-8
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产品详情
生物活性:
Sulmazole is a cardiotonic agent. Sulmazole has competitive inhibitory for A1 adenosine receptor. Sulmazole can improve cardiac index and reduce pulmonary capillary wedge pressure.
体外研究:
Sulmazole has competitive inhibitory for A1 adenosine receptors.Sulmazole attenuates the capacity of GTP to inhibit adenylate cyclase activity and covalent modification of Gi by pertussis toxin treatment abolishes the capacity of sulmazole to mediate stimulation.Sulmazole has stimulatory effect on adenylate cyclase activity in pertussis toxin-treated membranes.Sulmazole mediates increases in cAMP accumulation by mechanisms other than phosphodiesterase inhibition, including A1 adenosine receptor antagonism and inhibition of Gi function.