产品
编 号：F441570
分子式：C10H11F3N2O5.1/2C9H11ClN4O2.1/2HCl
分子量：435.76
分子式：C10H11F3N2O5.1/2C9H11ClN4O2.1/2HCl
分子量：435.76
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
50mg
询价
询价
100mg
询价
询价
结构图
CAS No: 733030-01-8
产品详情
生物活性：
Trifluridine/tipiracil hydrochloride mixture (TAS-102) is a potent and orally active nucleoside antitumor agent. The composition of Trifluridine/tipiracil hydrochloride mixture (TAS-102) is a 1:0.5 mixture (on a molar basis) of alpha,alpha,alpha-tri-fluorothymidine (FTD) and thymidine phosphorylase inhibitor (TPI). Trifluridine/tipiracil hydrochloride mixture (TAS-102) shows the antitumor activity mainly via the inhibition of thymidylate synthase (TS) and incorporation into DNA.
体内研究：
Trifluridine/tipiracil hydrochloride mixture (150 mg/kg/天；口服；每天两次，持续 14 天) 在结直肠癌和胃癌小鼠模型中防止体重减轻并减少相对肿瘤体积。Animal Model:Male nude mice bearing KM12C, KM12C/5-FU, DLD-1, DLD-1/5-FU, and SC-2 cells
Dosage:150 mg/kg/day
Administration:p.o.; twice a day for 14 days
Result:Prevented body weight loss and reduced the relative tumor volume in colorectal cancer and gastric cancer mice models.
Trifluridine/tipiracil hydrochloride mixture (TAS-102) is a potent and orally active nucleoside antitumor agent. The composition of Trifluridine/tipiracil hydrochloride mixture (TAS-102) is a 1:0.5 mixture (on a molar basis) of alpha,alpha,alpha-tri-fluorothymidine (FTD) and thymidine phosphorylase inhibitor (TPI). Trifluridine/tipiracil hydrochloride mixture (TAS-102) shows the antitumor activity mainly via the inhibition of thymidylate synthase (TS) and incorporation into DNA.
体内研究：
Trifluridine/tipiracil hydrochloride mixture (150 mg/kg/天；口服；每天两次，持续 14 天) 在结直肠癌和胃癌小鼠模型中防止体重减轻并减少相对肿瘤体积。Animal Model:Male nude mice bearing KM12C, KM12C/5-FU, DLD-1, DLD-1/5-FU, and SC-2 cells
Dosage:150 mg/kg/day
Administration:p.o.; twice a day for 14 days
Result:Prevented body weight loss and reduced the relative tumor volume in colorectal cancer and gastric cancer mice models.
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