产品
编 号：F441175
分子式：C9H11Cl3N4
分子量：281.57
分子式：C9H11Cl3N4
分子量：281.57
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
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1mg
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5mg
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10mg
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25mg
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结构图
CAS No: 73218-79-8
产品详情
生物活性：
Apraclonidine hydrochloride (ALO 2145), a selective α2 and weak α1 receptor agonist activity, effectively lowers intraocular pressure (IOP) in human eyes. Apraclonidine hydrochloride is a topical ophthalmic solution and has the ability to elevate the eye lid.
体内研究：
Apraclonidine hydrochloride (ALO 2145) is effective in animal models of elevated IOP as well as glaucoma in humans. The ocular hypotensive effects of Apraclonidine are usually attributed to reduced aqueous humor synthesis and vasoconstrictor actions at the anterior segment branches of the ophthalmic artery.Apraclonidine (1.15%, single instillation) inhibits 98% of PGE2-induced aqueous flare elevationy.Animal Model:male rabbits.
Dosage:1.15%
Administration:Apraclonidine (1.15%, single instillation)
Result:Inhibited PGE2-induced elevation of aqueous flare in pigmented rabbits.
体外研究：
Apraclonidine hydrochloride (ALO 2145) is more commonly used topically for glaucoma, as it penetrates the cornea and blood-brain barrier to a lesser extent and, thus, has fewer adverse systemic effects.
Apraclonidine hydrochloride (ALO 2145), a selective α2 and weak α1 receptor agonist activity, effectively lowers intraocular pressure (IOP) in human eyes. Apraclonidine hydrochloride is a topical ophthalmic solution and has the ability to elevate the eye lid.
体内研究：
Apraclonidine hydrochloride (ALO 2145) is effective in animal models of elevated IOP as well as glaucoma in humans. The ocular hypotensive effects of Apraclonidine are usually attributed to reduced aqueous humor synthesis and vasoconstrictor actions at the anterior segment branches of the ophthalmic artery.Apraclonidine (1.15%, single instillation) inhibits 98% of PGE2-induced aqueous flare elevationy.Animal Model:male rabbits.
Dosage:1.15%
Administration:Apraclonidine (1.15%, single instillation)
Result:Inhibited PGE2-induced elevation of aqueous flare in pigmented rabbits.
体外研究：
Apraclonidine hydrochloride (ALO 2145) is more commonly used topically for glaucoma, as it penetrates the cornea and blood-brain barrier to a lesser extent and, thus, has fewer adverse systemic effects.
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