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编 号：F440529
分子式：C20H21NO5
分子量：355.38
分子式：C20H21NO5
分子量：355.38
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CAS No: 73080-51-0
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生物活性：
Repirinast (MY-5116) is an orally active anti-allergic agent. Repirinast inhibits histamine release. Repirinast can be used in the research of bronchial asthma.
体内研究：
Repirinast (30 mg/kg, i.p.) inhibits antigen-induced early and late pulmonary responses in guinea pigs.Repirinast (30 mg/kg, p.o.) inhibits antigen-induced immediate bronchoconstriction in rats.Animal Model:Guinea pigs
Dosage:30 mg/kg
Administration:Intraperitoneal injection (i.p.)
Result:Inhibited leukocyte (predominantly eosinophils) infiltration into bronchial tissue. Blocked antigen-induced airway hyperresponsiveness to inhaled Acetylcholine.
Animal Model:Rat with asthma (challenged with 10 mg/kg antigen OVA)
Dosage:30 mg/kg
Administration:Oral administration (p.o.)
Result:Inhibited the decreases in the number Of breath at 30 sec and 1 min after challenge.
体外研究：
Repirinast inhibits histamine release from rat peritoneal mast cells induced by antigen (IC50: 0.3 μM).
Repirinast (MY-5116) is an orally active anti-allergic agent. Repirinast inhibits histamine release. Repirinast can be used in the research of bronchial asthma.
体内研究：
Repirinast (30 mg/kg, i.p.) inhibits antigen-induced early and late pulmonary responses in guinea pigs.Repirinast (30 mg/kg, p.o.) inhibits antigen-induced immediate bronchoconstriction in rats.Animal Model:Guinea pigs
Dosage:30 mg/kg
Administration:Intraperitoneal injection (i.p.)
Result:Inhibited leukocyte (predominantly eosinophils) infiltration into bronchial tissue. Blocked antigen-induced airway hyperresponsiveness to inhaled Acetylcholine.
Animal Model:Rat with asthma (challenged with 10 mg/kg antigen OVA)
Dosage:30 mg/kg
Administration:Oral administration (p.o.)
Result:Inhibited the decreases in the number Of breath at 30 sec and 1 min after challenge.
体外研究：
Repirinast inhibits histamine release from rat peritoneal mast cells induced by antigen (IC50: 0.3 μM).
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