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编 号：F440405
分子式：C137H207N41O39S3
分子量：3148.56
分子式：C137H207N41O39S3
分子量：3148.56
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CAS No: 73032-94-7
产品详情
生物活性：
Somatostatin-28 (sheep, human rat mouse) is a biologically active polypeptide, synthesised in the proximal intestinal epithelial cells. Somatostatin-28 (sheep, human rat mouse) suppresses glucose-stimulated insulin secretion without affecting circulating basal insulin concentration. Somatostatin-28 (sheep, human rat mouse) also targets to somatostatin receptor subtype 5 (SSTR5) to regulate GLP-1 secretion.
体内研究：
Somatostatin-28 (sheep) (1.1 pmol/kg/min; 通过颈静脉导管静脉注射; 15 min) 抑制 25 μg/kg/min 葡萄糖诱导绵羊胰岛素分泌。Animal Model:Finn-Dorset Horn cross bred sheep (2-5 years old, 70-75 kg)
Dosage:1.1 pmol/kg/min for 15 min, with or without 25 μg/kg/min glucose;
Administration:Intravenous injection via a jugular catheter;
Result:Significantly inhibited insulin secretion, resulted serum concentrations decreasing from about 200 to 150 pmol/L.
体外研究：
Somatostatin-28 剂量依赖地抑制胃泌素释放肽刺激的 GLP-1 分泌，EC50 为 0.01 nM。
Somatostatin-28 (sheep, human rat mouse) is a biologically active polypeptide, synthesised in the proximal intestinal epithelial cells. Somatostatin-28 (sheep, human rat mouse) suppresses glucose-stimulated insulin secretion without affecting circulating basal insulin concentration. Somatostatin-28 (sheep, human rat mouse) also targets to somatostatin receptor subtype 5 (SSTR5) to regulate GLP-1 secretion.
体内研究：
Somatostatin-28 (sheep) (1.1 pmol/kg/min; 通过颈静脉导管静脉注射; 15 min) 抑制 25 μg/kg/min 葡萄糖诱导绵羊胰岛素分泌。Animal Model:Finn-Dorset Horn cross bred sheep (2-5 years old, 70-75 kg)
Dosage:1.1 pmol/kg/min for 15 min, with or without 25 μg/kg/min glucose;
Administration:Intravenous injection via a jugular catheter;
Result:Significantly inhibited insulin secretion, resulted serum concentrations decreasing from about 200 to 150 pmol/L.
体外研究：
Somatostatin-28 剂量依赖地抑制胃泌素释放肽刺激的 GLP-1 分泌，EC50 为 0.01 nM。
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