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编 号:F439744
分子式:C19H28ClN5
分子量:361.91
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10mM*1mL in DMSO
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5mg
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10mg
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25mg
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50mg
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100mg
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Dapiprazole hydrochloride is a potent, selective and orally active alpha-1 adrenoceptor antagonist. Dapiprazole hydrochloride suppresses the opioid withdrawal symptoms. Dapiprazole hydrochloride is also used as eye drops for reversing mydriasis.

体内研究:
Dapiprazole hydrochloride (0-10 mg/kg or 0-3 mg/mice; i.p. or i.c.v.; once) reduces the overall severity of the opiate withdrawal symptoms in mice.Animal Model:Swiss Albino male CD-1 mice weighing 20 -25 g, acute dependence model
Dosage:5, 7.5 and 10 mg/kg (i.p.) or 0.5, 1 and 3 mg/mice (i.c.v.), once
Administration:Intraperitoneal injection or intracerebroventricular administration, once
Result:Decreased jumping behavior, head shakes and paw shakes when administered just before naloxone.
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