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编 号：F439743
分子式：C19H27N5
分子量：325.45
分子式：C19H27N5
分子量：325.45
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CAS No: 72822-12-9
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生物活性：
Dapiprazole is a potent, selective and orally active alpha-1 adrenoceptor antagonist. Dapiprazole suppresses the opioid withdrawal symptoms. Dapiprazole is also used as eye drops for reversing mydriasis.
体内研究：
Dapiprazole hydrochloride (0-10 mg/kg or 0-3 mg/mice; i.p. or i.c.v.; once) reduces the overall severity of the opiate withdrawal symptoms in mice.Animal Model:Swiss Albino male CD-1 mice weighing 20 -25 g, acute dependence model
Dosage:5, 7.5 and 10 mg/kg (i.p.) or 0.5, 1 and 3 mg/mice (i.c.v.), once
Administration:Intraperitoneal injection or intracerebroventricular administration, once
Result:Decreased jumping behavior, head shakes and paw shakes when administered just before naloxone.
Dapiprazole is a potent, selective and orally active alpha-1 adrenoceptor antagonist. Dapiprazole suppresses the opioid withdrawal symptoms. Dapiprazole is also used as eye drops for reversing mydriasis.
体内研究：
Dapiprazole hydrochloride (0-10 mg/kg or 0-3 mg/mice; i.p. or i.c.v.; once) reduces the overall severity of the opiate withdrawal symptoms in mice.Animal Model:Swiss Albino male CD-1 mice weighing 20 -25 g, acute dependence model
Dosage:5, 7.5 and 10 mg/kg (i.p.) or 0.5, 1 and 3 mg/mice (i.c.v.), once
Administration:Intraperitoneal injection or intracerebroventricular administration, once
Result:Decreased jumping behavior, head shakes and paw shakes when administered just before naloxone.
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