产品
编 号：F438269
分子式：C22H17Cl2N3O2S
分子量：458.36
分子式：C22H17Cl2N3O2S
分子量：458.36
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
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5mg
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10mg
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25mg
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50mg
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100mg
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结构图
CAS No: 724453-98-9
产品详情
生物活性：
Diflapolin is a highly active dual 5-lipoxygenase-activating protein (FLAP)/soluble epoxide hydrolase (sEH) inhibitor with marked anti-inflammatory efficacy and high target selectivity. Diflapolin inhibits 5-LOX product formation in intact human monocytes and neutrophils with IC50s?of? 30 and 170?nM, respectively, and suppressed the activity of isolated sEH (IC50=20?nM).
体内研究：
Diflapolin (1-10 mg/kg; i.p.; 30?min before zymosan injection) exhibits potent anti-inflammatory properties in in-vivo experiments.Animal Model:Male CD-1 mice (zymosan-induced peritonitis mouse model)
Dosage:1, 3 and 10?mg/kg
Administration:I.p.; 30?min before zymosan injection
Result:Induced a significant reduction of LTC4 and LTB4 peritoneal levels, starting from the dose of 1?mg/kg and comparable to the effect of MK886.
Diflapolin is a highly active dual 5-lipoxygenase-activating protein (FLAP)/soluble epoxide hydrolase (sEH) inhibitor with marked anti-inflammatory efficacy and high target selectivity. Diflapolin inhibits 5-LOX product formation in intact human monocytes and neutrophils with IC50s?of? 30 and 170?nM, respectively, and suppressed the activity of isolated sEH (IC50=20?nM).
体内研究：
Diflapolin (1-10 mg/kg; i.p.; 30?min before zymosan injection) exhibits potent anti-inflammatory properties in in-vivo experiments.Animal Model:Male CD-1 mice (zymosan-induced peritonitis mouse model)
Dosage:1, 3 and 10?mg/kg
Administration:I.p.; 30?min before zymosan injection
Result:Induced a significant reduction of LTC4 and LTB4 peritoneal levels, starting from the dose of 1?mg/kg and comparable to the effect of MK886.
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