产品
编 号：F438252
分子式：C20H14ClNO5S
分子量：415.85
分子式：C20H14ClNO5S
分子量：415.85
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
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10mg
询价
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50mg
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100mg
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询价
结构图
CAS No: 724440-27-1
产品详情
生物活性：
BAY-8002 is a potent, selective, orally active inhibitor of monocarboxylate transporter 1 (MCT1), with an IC50 of 85 nM in the MCT1-expressing DLD-1 cells, displays excellent selectivity against MCT4. Anti-tumor activity.
体内研究：
BAY-8002 (80 and 160 mg/kg, p.o., twice daily, for more than 26 days) significantly inhibits tumor growth in Raji tumor-bearing mice.Animal Model:Female NOD SCID mice bearing Raji cells (7-10 weeks old)
Dosage:80 and 160 mg/kg
Administration:P.O. twice daily for more than 26 days
Result:Inhibited tumor growth with no obvious body weight loss, but showed no effect on tumor regression.
体外研究：
BAY-8002 is an inhibitor of MCT1, with an IC50 of 85 nM in the MCT1-expressing DLD-1 cells, displays excellent selectivity against MCT4 (IC50 >50 μM in EVSA-T cells).
BAY-8002 is a potent, selective, orally active inhibitor of monocarboxylate transporter 1 (MCT1), with an IC50 of 85 nM in the MCT1-expressing DLD-1 cells, displays excellent selectivity against MCT4. Anti-tumor activity.
体内研究：
BAY-8002 (80 and 160 mg/kg, p.o., twice daily, for more than 26 days) significantly inhibits tumor growth in Raji tumor-bearing mice.Animal Model:Female NOD SCID mice bearing Raji cells (7-10 weeks old)
Dosage:80 and 160 mg/kg
Administration:P.O. twice daily for more than 26 days
Result:Inhibited tumor growth with no obvious body weight loss, but showed no effect on tumor regression.
体外研究：
BAY-8002 is an inhibitor of MCT1, with an IC50 of 85 nM in the MCT1-expressing DLD-1 cells, displays excellent selectivity against MCT4 (IC50 >50 μM in EVSA-T cells).
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