产品
编 号：F438213
分子式：C12H13NO3
分子量：219.24
分子式：C12H13NO3
分子量：219.24
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
500mg
400
In-stock
1g
576
In-stock
5g
1976
In-stock
结构图
CAS No: 72432-10-1
产品详情
生物活性：
Aniracetam (Ro 13-5057) is an orally active neuroprotective agent, possessing nootropics effects. Aniracetam potentiates the ionotropic quisqualate (iQA) responses in the CA1 region of rat hippocampal slices. Aniracetam also potentiates the excitatory post synaptic potentials (EPSPs) in Schaffer collateral-commissural synapses. Aniracetam can prevents the CO2-induced impairment of acquisition in hypercapnia model rats. Aniracetam can be used to research cerebral dysfunctional disorders.
体内研究：
Aniracetam (1 mM; 30-75 min) potentiates the iQA receptors and produces remarkable facilitation of the native synaptic transmission in rats.Aniracetam (10-100 mg/kg; p.o.; single dosage) prevents the CO2-induced impairment of acquisition in rats.Aniracetam (30-300 mg/kg; p.o.; single dosage) increases the percentage of rats showing passive avoidance.Animal Model:Pyramidal neurons from male Wistar rats
Dosage:1 mM
Administration:30-75 min
Result:Potentiated the iQA receptors existing in the brain and produced remarkable facilitation of the native synaptic transmission.
Animal Model:Male rats (100-120 g; hypercapnia induced by pure CO2)
Dosage:10, 30, 50 and 100 mg/kg
Administration:p.o.; single dosage (60 min before hypercapnia)
Result:Significantly prevented the CO2-induced impairment of acquisition at 30 and 50 mg/kg.
Animal Model:Male rats and male mice (100-120 g and 21-25 g; 0.5 mg/kg Scopolamine-induced transient disruption of the memory of a passive avoidance procedure)
Dosage:30, 50, 100 and 300 mg/kg,
Administration:p.o.; single dosage
Result:Significantly increased the percentage of rats showing passive avoidance 2 h after Scopolamine (HY-N0296) at 50 and 100 mg/kg.
体外研究：
Aniracetam concentration-dependently counteracts glutsmate-, kainate-, or α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-induced cell death and greatly facilitated neuroprotective response achieved by different concentrations of both quisqualate and trans-1-aminocyclopentane-1, 3-dicarboxylate in primary cultures of cerebellar granule cells.Aniracetam potentiates the mGluR-coupled stimulation of phospholipase C in primary cultures of cerebellar granule cells.
Aniracetam (Ro 13-5057) is an orally active neuroprotective agent, possessing nootropics effects. Aniracetam potentiates the ionotropic quisqualate (iQA) responses in the CA1 region of rat hippocampal slices. Aniracetam also potentiates the excitatory post synaptic potentials (EPSPs) in Schaffer collateral-commissural synapses. Aniracetam can prevents the CO2-induced impairment of acquisition in hypercapnia model rats. Aniracetam can be used to research cerebral dysfunctional disorders.
体内研究：
Aniracetam (1 mM; 30-75 min) potentiates the iQA receptors and produces remarkable facilitation of the native synaptic transmission in rats.Aniracetam (10-100 mg/kg; p.o.; single dosage) prevents the CO2-induced impairment of acquisition in rats.Aniracetam (30-300 mg/kg; p.o.; single dosage) increases the percentage of rats showing passive avoidance.Animal Model:Pyramidal neurons from male Wistar rats
Dosage:1 mM
Administration:30-75 min
Result:Potentiated the iQA receptors existing in the brain and produced remarkable facilitation of the native synaptic transmission.
Animal Model:Male rats (100-120 g; hypercapnia induced by pure CO2)
Dosage:10, 30, 50 and 100 mg/kg
Administration:p.o.; single dosage (60 min before hypercapnia)
Result:Significantly prevented the CO2-induced impairment of acquisition at 30 and 50 mg/kg.
Animal Model:Male rats and male mice (100-120 g and 21-25 g; 0.5 mg/kg Scopolamine-induced transient disruption of the memory of a passive avoidance procedure)
Dosage:30, 50, 100 and 300 mg/kg,
Administration:p.o.; single dosage
Result:Significantly increased the percentage of rats showing passive avoidance 2 h after Scopolamine (HY-N0296) at 50 and 100 mg/kg.
体外研究：
Aniracetam concentration-dependently counteracts glutsmate-, kainate-, or α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-induced cell death and greatly facilitated neuroprotective response achieved by different concentrations of both quisqualate and trans-1-aminocyclopentane-1, 3-dicarboxylate in primary cultures of cerebellar granule cells.Aniracetam potentiates the mGluR-coupled stimulation of phospholipase C in primary cultures of cerebellar granule cells.
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