产品
编 号：F437966
分子式：C21H26O2
分子量：310.43
分子式：C21H26O2
分子量：310.43
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
100mg
560
In-stock
结构图
CAS No: 72-33-3
产品详情
生物活性：
Mestranol is an inactive proagent and becomes biologically active on conversion to ethinyl estradiol (EE). Mestranol acts as an estrogen receptor agonist. Mestranol combines with a progestin in vivo and can be used for the research of menopausal hormone or menstrual disorders. Mestranol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
体外研究：
Mestranol is a low potency synthetic estrogen that has been shown to be much more stable than 17β-Estradiol(HY-B0141) in hepatoma cell culture.Mestranol (10 μM; 6 days) stimulates the growth ofERpositive MCF-7 WS8 cells up to 250% of control levels, growth stimulation could be partially reversed by tamoxifen.However, in Hep G2 hepatoma cells, Mestranol (10 μM; 6 days) inhibits the growth of Hep 3B cells by 40% compared to control cells. Mestranol alone or cotreatment with tamoxifen both can inhibit cell growth. And cotreatment exhibits an additive effect with tamoxifen on growth inhibition.
Mestranol is an inactive proagent and becomes biologically active on conversion to ethinyl estradiol (EE). Mestranol acts as an estrogen receptor agonist. Mestranol combines with a progestin in vivo and can be used for the research of menopausal hormone or menstrual disorders. Mestranol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
体外研究：
Mestranol is a low potency synthetic estrogen that has been shown to be much more stable than 17β-Estradiol(HY-B0141) in hepatoma cell culture.Mestranol (10 μM; 6 days) stimulates the growth ofERpositive MCF-7 WS8 cells up to 250% of control levels, growth stimulation could be partially reversed by tamoxifen.However, in Hep G2 hepatoma cells, Mestranol (10 μM; 6 days) inhibits the growth of Hep 3B cells by 40% compared to control cells. Mestranol alone or cotreatment with tamoxifen both can inhibit cell growth. And cotreatment exhibits an additive effect with tamoxifen on growth inhibition.
产品资料
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