产品
编 号：F437698
分子式：C6H4K2NO8V
分子量：347.24
分子式：C6H4K2NO8V
分子量：347.24
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
结构图
CAS No: 722494-26-0
产品详情
生物活性：
BpV(HOpic) is a potent and selective inhibitor of PTEN with an IC50 of 14 nM. Nanocarrier-BpV(HOpic) has neuroprotective activity.
体内研究：
BpV(HOpic (0.05 mg/kg；ip) 在再灌注时改善体内肝缺血/再灌注 (I/R) 损伤。 BpV(HOpic (200 μg/kg；ip) 在缺血/再灌注损伤 (IRI) 小鼠中加剧肾功能障碍并促进肾小管损伤。Animal Model:Male Wistar rats are subjected to partial hepatic ischemia
Dosage:0.05 mg/kg
Administration:I.p. injections at the start of reperfusion
Result:Ameliorated reoxygenation injury and reproduced the hepatoprotective effects obtained by adenosine A2A receptor stimulation.
Animal Model:Male C57BL/6 mice (8-12 weeks old; 20-30 g ) are subjected to renal ischemia
Dosage:200?μg/kg
Administration:I.p. injections 1?h before ischemia and then administers every 6?h after ischemia for 24 hr
Result:Raised the level of serum creatinine and blood serum urea nitrogen.
体外研究：
BpV(HOpic (1 μM) 处理在接受顺铂处理的 MG63 细胞中增加细胞增殖并降低凋亡率。 Bpv (HOpic) (1 μM) 增强 C2C12 成肌细胞的迁移并且与 PI3K/AKT 和 MAPK/ERK 信号通路的激活有关。 BpV(HOpic (1 μM；48 小时) 促进猪卵泡生长和发育的启动，与啮齿类动物和人类相似。纳米载体- BpV(HOpic 增强神经元的轴突生长。
BpV(HOpic) is a potent and selective inhibitor of PTEN with an IC50 of 14 nM. Nanocarrier-BpV(HOpic) has neuroprotective activity.
体内研究：
BpV(HOpic (0.05 mg/kg；ip) 在再灌注时改善体内肝缺血/再灌注 (I/R) 损伤。 BpV(HOpic (200 μg/kg；ip) 在缺血/再灌注损伤 (IRI) 小鼠中加剧肾功能障碍并促进肾小管损伤。Animal Model:Male Wistar rats are subjected to partial hepatic ischemia
Dosage:0.05 mg/kg
Administration:I.p. injections at the start of reperfusion
Result:Ameliorated reoxygenation injury and reproduced the hepatoprotective effects obtained by adenosine A2A receptor stimulation.
Animal Model:Male C57BL/6 mice (8-12 weeks old; 20-30 g ) are subjected to renal ischemia
Dosage:200?μg/kg
Administration:I.p. injections 1?h before ischemia and then administers every 6?h after ischemia for 24 hr
Result:Raised the level of serum creatinine and blood serum urea nitrogen.
体外研究：
BpV(HOpic (1 μM) 处理在接受顺铂处理的 MG63 细胞中增加细胞增殖并降低凋亡率。 Bpv (HOpic) (1 μM) 增强 C2C12 成肌细胞的迁移并且与 PI3K/AKT 和 MAPK/ERK 信号通路的激活有关。 BpV(HOpic (1 μM；48 小时) 促进猪卵泡生长和发育的启动，与啮齿类动物和人类相似。纳米载体- BpV(HOpic 增强神经元的轴突生长。
产品资料
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