产品
编 号：F437539
分子式：C8H9Cl3N2S
分子量：271.59
分子式：C8H9Cl3N2S
分子量：271.59
产品类型
规格
价格
是否有货
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
50mg
询价
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100mg
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结构图
CAS No: 72214-67-6
产品详情
生物活性：
RRD-251 is an inhibitor of retinoblastoma tumor suppressor protein (Rb)-Raf-1 interaction, with potent anti-proliferative, anti-angiogenic and anti-tumor activities.
体内研究：
RRD-251 (50 mg/kg; i.p.; q.o.d; for 14 days) has anti-cancer activities in vivo on melanomas.Animal Model:8-wk-old female athymic nude mice, with SK-ME-28 xenograft
Dosage:50 mg/kg
Administration:Intraperitoneal administration, qod, for 14 days
Result:Inhibits the growth of SK-ME-28 xenograft in nude mice.
体外研究：
RRD-251 (10-50 μM; 24 hours) inhibits melanoma growth in-vitro.RRD-251 (50 μM; 2 hours) inhibits Rb-Raf-1 interaction and Rb phosphorylation in non-small cell lung cancer cells. RRD-251 induces apoptosis (50 μM; 18 hours) and cell cycle arrest (20-50 μM; 4 hours).RRD-251 alters the expression of cell cycle and apoptosis regulatory protein.
RRD-251 is an inhibitor of retinoblastoma tumor suppressor protein (Rb)-Raf-1 interaction, with potent anti-proliferative, anti-angiogenic and anti-tumor activities.
体内研究：
RRD-251 (50 mg/kg; i.p.; q.o.d; for 14 days) has anti-cancer activities in vivo on melanomas.Animal Model:8-wk-old female athymic nude mice, with SK-ME-28 xenograft
Dosage:50 mg/kg
Administration:Intraperitoneal administration, qod, for 14 days
Result:Inhibits the growth of SK-ME-28 xenograft in nude mice.
体外研究：
RRD-251 (10-50 μM; 24 hours) inhibits melanoma growth in-vitro.RRD-251 (50 μM; 2 hours) inhibits Rb-Raf-1 interaction and Rb phosphorylation in non-small cell lung cancer cells. RRD-251 induces apoptosis (50 μM; 18 hours) and cell cycle arrest (20-50 μM; 4 hours).RRD-251 alters the expression of cell cycle and apoptosis regulatory protein.
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