产品
编 号：F436776
分子式：C10H11N5Na3O13P3
分子量：571.11
分子式：C10H11N5Na3O13P3
分子量：571.11
产品类型
规格
价格
是否有货
5mg
询价
询价
结构图
CAS No: 71997-40-5
产品详情
生物活性：
Oxidized ATP (oATP) trisodium salt is a broad-spectrum P2 receptor inhibitor. Oxidized ATP trisodium salt irreversibly antagonizes P2X7R activation. Oxidized ATP trisodium salt inhibits c-reactive protein (CRP)-induced NLRP3 inflammasome activation. Oxidized ATP trisodium salt can be used for research of atherosclerosis.
体内研究：
Oxidized ATP (300 μg/mouse, i.p., twice a week) trisodium salt ameliorates the induced mouse experimental autoimmune uveitis (EAU) in B6 mice.Animal Model:Induced mouse experimental autoimmune uveitis (EAU)
Dosage:300 μg/mouse
Administration:i.p.
Result:Showed almost undetected EAU, as shown by fundoscopic and pathologic examination.Decreased serum IL-17 level.Mitigated the autoreactive T cell response.
体外研究：
Oxidized ATP trisodium salt (100 μM，1 小时) 抑制 HUVEC 中 CRP (20 μg/mL，24 小时) 诱导的 caspase-1 激活和 IL-1β 成熟。
Oxidized ATP (oATP) trisodium salt is a broad-spectrum P2 receptor inhibitor. Oxidized ATP trisodium salt irreversibly antagonizes P2X7R activation. Oxidized ATP trisodium salt inhibits c-reactive protein (CRP)-induced NLRP3 inflammasome activation. Oxidized ATP trisodium salt can be used for research of atherosclerosis.
体内研究：
Oxidized ATP (300 μg/mouse, i.p., twice a week) trisodium salt ameliorates the induced mouse experimental autoimmune uveitis (EAU) in B6 mice.Animal Model:Induced mouse experimental autoimmune uveitis (EAU)
Dosage:300 μg/mouse
Administration:i.p.
Result:Showed almost undetected EAU, as shown by fundoscopic and pathologic examination.Decreased serum IL-17 level.Mitigated the autoreactive T cell response.
体外研究：
Oxidized ATP trisodium salt (100 μM，1 小时) 抑制 HUVEC 中 CRP (20 μg/mL，24 小时) 诱导的 caspase-1 激活和 IL-1β 成熟。
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