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编 号:F435837
分子式:C13H26N4O6
分子量:334.37
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生物活性:
Threonyl-seryl-lysine, a bovine pineal antireproductive tripeptide, has antigonadotropic activity. Threonyl-seryl-lysine binds to luteinizing hormone-releasing hormone (LHRH) at a site comprised of LHRH 2-5.

体内研究:
Threonyl-seryl-lysine (175 ng, i.p.) reduces the 5-day compensatory ovarian hypertrophy in unilaterally ovariectomized (UO) mice.Threonyl-seryl-lysine (1 or 5 μg, i.p.) delays vaginal opening time in female Charles River CD rats.Threonyl-seryl-lysine (1 and 10 μg, s.c., for 15 days) increases the weight of ovaries and of adrenals in mice.Animal Model:Unilaterally ovariectomized (UO) mice
Dosage:175 ng
Administration:Intraperitoneal injection (i.p.)
Result:Reduced serum follicle stimulating hormone (FSH) in UO mice.
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