产品
编 号：F435021
分子式：C18H11F3N2O3
分子量：360.29
分子式：C18H11F3N2O3
分子量：360.29
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
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1mg
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5mg
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10mg
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25mg
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50mg
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结构图
CAS No: 714971-87-6
产品详情
生物活性：
RO0711401 is a selective and orally active positive allosteric modulator of mGlu1 receptor with an EC50 of 56 nM.
体内研究：
RO0711401 (10 mg/kg; s.c.; once) causes a long-lasting improvement in motor performance, which is maintained to the same extent at least for 6 days.Systemic injection of RO0711401 is shown to reduce the frequency of spike-and-wave discharges in a rat model of absence epilepsy, and to improve motor signs in autoimmune encephalomyelitis (EAE) mice.Animal Model:Spinocerebellar ataxia type 1 (SCA1) mice (30-week old)
Dosage:10 mg/kg
Administration:Subcutaneous injection; once
Result:Caused a prolonged improvement of motor performance on the rotarod and the paw-print tests.
RO0711401 is a selective and orally active positive allosteric modulator of mGlu1 receptor with an EC50 of 56 nM.
体内研究：
RO0711401 (10 mg/kg; s.c.; once) causes a long-lasting improvement in motor performance, which is maintained to the same extent at least for 6 days.Systemic injection of RO0711401 is shown to reduce the frequency of spike-and-wave discharges in a rat model of absence epilepsy, and to improve motor signs in autoimmune encephalomyelitis (EAE) mice.Animal Model:Spinocerebellar ataxia type 1 (SCA1) mice (30-week old)
Dosage:10 mg/kg
Administration:Subcutaneous injection; once
Result:Caused a prolonged improvement of motor performance on the rotarod and the paw-print tests.
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