产品
编 号：F434420
分子式：C13H17ClN2O2
分子量：268.74
分子式：C13H17ClN2O2
分子量：268.74
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
228
In-stock
10mg
364
In-stock
25mg
656
In-stock
50mg
1027
In-stock
100mg
1529
In-stock
结构图
CAS No: 71320-77-9
产品详情
生物活性：
Moclobemide (Ro111163) is a brain-penetrant and reversible monoamine oxidase (MAO-A) inhibitor with an IC50 of 6.061 μM for hMAO-A.Moclobemide up-regulates proliferation of hippocampal progenitor cells in chronically stressed mice.
体内研究：
Moclobemide is a monoamine oxidase inhibitor and increases the levels of brain monoamines (such as 5-HT, norepinephrine).Moclobemide(40 mg/kg) is effective in animal behavior models.Animal Model:Chronically stressed male mice (18±2 g) of the Kunming strain
Dosage:40 mg/kg
Administration:I.p.; daily
Result:BDNF level in the hippocampal subfields including subgranule zone decreased in stressed mice compared with normal control. Chronic treatment with Moclobemide could reverse these changes.
体外研究：
NMDA (600 μM for 3 days) inhibits the proliferation of PC12 cells.Moclobemide (2 and 10 μM) up-regulates the proliferation in NMDA-treated PC12 cells.
Moclobemide (Ro111163) is a brain-penetrant and reversible monoamine oxidase (MAO-A) inhibitor with an IC50 of 6.061 μM for hMAO-A.Moclobemide up-regulates proliferation of hippocampal progenitor cells in chronically stressed mice.
体内研究：
Moclobemide is a monoamine oxidase inhibitor and increases the levels of brain monoamines (such as 5-HT, norepinephrine).Moclobemide(40 mg/kg) is effective in animal behavior models.Animal Model:Chronically stressed male mice (18±2 g) of the Kunming strain
Dosage:40 mg/kg
Administration:I.p.; daily
Result:BDNF level in the hippocampal subfields including subgranule zone decreased in stressed mice compared with normal control. Chronic treatment with Moclobemide could reverse these changes.
体外研究：
NMDA (600 μM for 3 days) inhibits the proliferation of PC12 cells.Moclobemide (2 and 10 μM) up-regulates the proliferation in NMDA-treated PC12 cells.
产品资料
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