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编 号:F433825
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5mg
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10mg
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25mg
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50mg
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100mg
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生物活性:
Hydroxypropylmethyl cellulose acetate succinate (Mw: 20-100k Da) is a cosolvent for preparing SDDs of low-solubility agents. Hydroxypropylmethyl cellulose acetate succinate (Mw: 20-100k Da) exhibits no acute/subchronic/chronic toxicity in rats, with oral activity and LD50 >2.5 g/kg.

体内研究:
Hydroxypropylmethyl cellulose acetate succinate(2.5 g/kg;p.o.;单剂量)在大鼠无显著急性毒性。Hydroxypropylmethyl cellulose acetate succinate(0.63、1.25、2.5 g/kg;p.o.;每日一次,连续 2 个月,每周 6 天)在大鼠无显著亚慢性毒性。Hydroxypropylmethyl cellulose acetate succinate(1.25 g/kg、2.5 g/kg;口服;每天一次,连续 2 个月,每周 6 天)在大鼠无显著慢性毒性。
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