产品
编 号:F432069
分子式:C26H28FN5O
分子量:445.53
产品类型
结构图
CAS No: 705946-27-6
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产品详情
生物活性:
Tyrosine kinase-IN-1 is a multi-targeted tyrosine kinase inhibitor with IC50s of 4, 20, 4, 2 nM for KDR, Flt-1, FGFR1 and PDGFRα, respectively.
体内研究:
Tyrosine kinase-IN-1 shows a reasonable PK profile (AUC(0–∞)=1.9, t1/2=4.6 h). It has a favorable oral bioavailability (F=63%) in rats.
体外研究:
Tyrosine kinase-IN-1 is from reference (compound 8K).