产品
编 号：F431803
分子式：C25H48N6O8
分子量：560.68
分子式：C25H48N6O8
分子量：560.68
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 70-51-9
产品详情
生物活性：
Deferoxamine (Deferoxamine B) is an iron chelator (binds to Fe(III) and many other metal cations), is widely used to reduce iron accumulation and deposition in tissues. Deferoxamine upregulates HIF-1α levels with good antioxidant activity. Deferoxamine also shows anti-proliferative activity, can induce apoptosis and autophagy in cancer cells. Deferoxamine can be used in studies of diabetes, neurodegenerative diseases as well as anti-cancer and anti-COVID-19.
体内研究：
Deferoxamine (560.68 mg/per; drip-on; once daily for 21 days) enhances wound healing and increases neovascularization in aged or diabetic mice.Deferoxamine (200 mg/kg; i.p.; daily for 2 weeks) results in HIF-1α stabilization and increases glucose uptake, hepatic InsR expression, and signaling in vivo.Animal Model:Aged (21-month-old) and diabetic (12-week-old) C57BL/6J mice (excisional wound model).
Dosage:560.68 mg/per (10 uL of 1 mM)
Administration:Drip-on; once daily for 21 days.
Result:Displayed significantly accelerated healing and increased neovascularization in both aged and diabetic mice model.
Animal Model:Male Sprague-Dawley rats (180-200 g).
Dosage:200 mg/kg
Administration:Intraperitoneal injection; daily for 2 weeks.
Result:Significantly increased hepatic HIF-1α protein levels, InsR protein levels, as well as Akt/PKB and activated Akt/PKB were significantly higher in the liver.
体外研究：
Deferoxamine (1 mM; 16 h or 4 weeks) improves HIF-1α function under hypoxic and hyperglycemic conditions and decreases ROS in MEFs cells.Deferoxamine (100 μM; 24 h) increases InsR expression and activity and also induces an increase in p-Akt/total Akt/PKB levels.Deferoxamine (5, 10, 25, 50, 100 μM; 7 or 9 days) inhibits the proliferation of tumor-associated MSCs and bone marrow MSCs.Deferoxamine (5, 10, 25, 50, 100 μM; 7 days) induces apoptosis of MSCs.Deferoxamine (10 μM ; 3 days) influencs the expression of adhesion proteins on MSCs.Deferoxamine (100 μM; 24 h) induces autophagy mediated by the level of HIF-1α in SH-SY5Y cells.
Deferoxamine (Deferoxamine B) is an iron chelator (binds to Fe(III) and many other metal cations), is widely used to reduce iron accumulation and deposition in tissues. Deferoxamine upregulates HIF-1α levels with good antioxidant activity. Deferoxamine also shows anti-proliferative activity, can induce apoptosis and autophagy in cancer cells. Deferoxamine can be used in studies of diabetes, neurodegenerative diseases as well as anti-cancer and anti-COVID-19.
体内研究：
Deferoxamine (560.68 mg/per; drip-on; once daily for 21 days) enhances wound healing and increases neovascularization in aged or diabetic mice.Deferoxamine (200 mg/kg; i.p.; daily for 2 weeks) results in HIF-1α stabilization and increases glucose uptake, hepatic InsR expression, and signaling in vivo.Animal Model:Aged (21-month-old) and diabetic (12-week-old) C57BL/6J mice (excisional wound model).
Dosage:560.68 mg/per (10 uL of 1 mM)
Administration:Drip-on; once daily for 21 days.
Result:Displayed significantly accelerated healing and increased neovascularization in both aged and diabetic mice model.
Animal Model:Male Sprague-Dawley rats (180-200 g).
Dosage:200 mg/kg
Administration:Intraperitoneal injection; daily for 2 weeks.
Result:Significantly increased hepatic HIF-1α protein levels, InsR protein levels, as well as Akt/PKB and activated Akt/PKB were significantly higher in the liver.
体外研究：
Deferoxamine (1 mM; 16 h or 4 weeks) improves HIF-1α function under hypoxic and hyperglycemic conditions and decreases ROS in MEFs cells.Deferoxamine (100 μM; 24 h) increases InsR expression and activity and also induces an increase in p-Akt/total Akt/PKB levels.Deferoxamine (5, 10, 25, 50, 100 μM; 7 or 9 days) inhibits the proliferation of tumor-associated MSCs and bone marrow MSCs.Deferoxamine (5, 10, 25, 50, 100 μM; 7 days) induces apoptosis of MSCs.Deferoxamine (10 μM ; 3 days) influencs the expression of adhesion proteins on MSCs.Deferoxamine (100 μM; 24 h) induces autophagy mediated by the level of HIF-1α in SH-SY5Y cells.
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