产品
编 号:F431387
分子式:C20H22O3
分子量:310.39
产品类型
结构图
CAS No: 70356-09-1
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生物活性:
Avobenzone, a dibenzoylmethane compound, is one of the most widely used filters in sunscreens for skin photoprotection in the UVA band. Avobenzone is an endocrine disruptor that directly binds to estrogen receptor β and acts as an estrogen agonist.
体外研究:
Avobenzone (EC50=14.1 μM) significantly promots adipogenesis in hBM-MSCs as its positive control obesogenic chemicals. Avobenzone (10 μM) significantly up-regulates mRNA levels of PPARγ during adipogenesis in hBM-MSCs.Avobenzone (1-50 μM; 48 hours) inhibits proliferative activities of human trophoblast cells.Avobenzone (1-50 μM; 48 hours) induces apoptosis in HTR8/SVneo cells.Avobenzone only shows weak ERa agonism and weak AR antagonism.