产品
编 号：F431297
分子式：C13H6Cl6O2
分子量：406.9
分子式：C13H6Cl6O2
分子量：406.9
产品类型
规格
价格
是否有货
100mg
询价
询价
500mg
询价
询价
1g
询价
询价
结构图
CAS No: 70-30-4
产品详情
生物活性：
Hexachlorophene (Hexachlorofen) is an effective anti-bacterial and antifungal agent. Hexachlorophene can cause lysis of protoplasts and leakage of intracellular contents in bacterial. Hexachlorophene is an inhibitor of SARS-CoV 3CL protease with an IC50 value of 5 μM. Hexachlorophene is also a potent KCNQ1/KCNE1 potassium channel activator with an EC50 value of 4.61 μM. Hexachlorophene inhibits Wnt/β-catenin signaling as well, and can be used in the research of arrhythmia, bacterial, cancers.
体内研究：
Hexachlorophene (tail immersion for 5 minutes, 1.25% w/v, one day prior to cercarial exposure) has inhibitory activity against Schistosoma mansoni infections in mice (exposed to WRAIR,Puerto Rican strain).Hexachlorophene has acute and subacute toxic effects with i.p. LD50 ranged between 21.8 mg/kg-40.0 mg/kg, and the oral LD50 varied from 57.6 to 87.0 mg/kg, respectively.Animal Model:Wistar rats (acute and subacute assays)
Dosage:0-100 mg/kg approximately
Administration:Intraperitoneal injection or oral administration
Result:Displayed acute and subacute toxic effects with i.p. LD50 ranged between 21.8 mg/kg-40.0 mg/kg, and the oral LD50 varied from 57.6 to 87.0 mg/kg, respectively.
体外研究：
Hexachlorophene (0.1-10 μM approximately) increases the current amplitude of KCNQ1/KCNE1 with an EC50 value of 4.61 μM, and shortens the action potential.Hexachlorophene (10 μM) rescues the loss of function of the LQTs mutants caused by either impaired activation gating or PIP2 binding affinity in CHO cells.Hexachlorophene (0-50 μg/mL approximately, 30 min) has antibacterial activities against micrococcus sp., staphylococcus, staphylococcus epidermidis and streptococcus with IC50 values of 0.83 μg/mL, 1.5 μg/mL, 1.75 μg/mL, 1.3 μg/mL, respectively.Hexachlorophene (20 μM, 15 h) inhibits Wnt/β-catenin signaling through the Siah-1-mediated β-catenin degradation in HEK293 and HCT116 cells.Hexachlorophene (0-10 μM, 48 h) inhibits the growth of HCT116 cells.Hexachlorophene is a competitive inhibitor of SARS-CoV 3CL with an IC50 value of 5 μM, and can form hydrogen bonds with SARS-CoV 3CL with Ki value estimated to be 4 μM.
Hexachlorophene (Hexachlorofen) is an effective anti-bacterial and antifungal agent. Hexachlorophene can cause lysis of protoplasts and leakage of intracellular contents in bacterial. Hexachlorophene is an inhibitor of SARS-CoV 3CL protease with an IC50 value of 5 μM. Hexachlorophene is also a potent KCNQ1/KCNE1 potassium channel activator with an EC50 value of 4.61 μM. Hexachlorophene inhibits Wnt/β-catenin signaling as well, and can be used in the research of arrhythmia, bacterial, cancers.
体内研究：
Hexachlorophene (tail immersion for 5 minutes, 1.25% w/v, one day prior to cercarial exposure) has inhibitory activity against Schistosoma mansoni infections in mice (exposed to WRAIR,Puerto Rican strain).Hexachlorophene has acute and subacute toxic effects with i.p. LD50 ranged between 21.8 mg/kg-40.0 mg/kg, and the oral LD50 varied from 57.6 to 87.0 mg/kg, respectively.Animal Model:Wistar rats (acute and subacute assays)
Dosage:0-100 mg/kg approximately
Administration:Intraperitoneal injection or oral administration
Result:Displayed acute and subacute toxic effects with i.p. LD50 ranged between 21.8 mg/kg-40.0 mg/kg, and the oral LD50 varied from 57.6 to 87.0 mg/kg, respectively.
体外研究：
Hexachlorophene (0.1-10 μM approximately) increases the current amplitude of KCNQ1/KCNE1 with an EC50 value of 4.61 μM, and shortens the action potential.Hexachlorophene (10 μM) rescues the loss of function of the LQTs mutants caused by either impaired activation gating or PIP2 binding affinity in CHO cells.Hexachlorophene (0-50 μg/mL approximately, 30 min) has antibacterial activities against micrococcus sp., staphylococcus, staphylococcus epidermidis and streptococcus with IC50 values of 0.83 μg/mL, 1.5 μg/mL, 1.75 μg/mL, 1.3 μg/mL, respectively.Hexachlorophene (20 μM, 15 h) inhibits Wnt/β-catenin signaling through the Siah-1-mediated β-catenin degradation in HEK293 and HCT116 cells.Hexachlorophene (0-10 μM, 48 h) inhibits the growth of HCT116 cells.Hexachlorophene is a competitive inhibitor of SARS-CoV 3CL with an IC50 value of 5 μM, and can form hydrogen bonds with SARS-CoV 3CL with Ki value estimated to be 4 μM.
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