产品
编 号：F431207
分子式：C26H33NO5
分子量：439.54
分子式：C26H33NO5
分子量：439.54
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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1mg
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5mg
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10mg
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25mg
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50mg
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结构图
CAS No: 702681-67-2
产品详情
生物活性：
CP-868388 free base is a potent, selective and orally active PPARα agonist with a Ki value of 10.8 nM. CP-868388 free base has little or no affinity for PPARβ (Ki of 3.47 μM) and PPARγ. CP-868388 free base has hypolipidemic and anti-inflammatory actions.
体内研究：
CP-868388 (0-3 mg/kg; oral gavage; once daily; for 2 days; male B6/CBF1J mice) treatment shows a robust and highly significant decrease in circulating plasma triglycerides. Triglyceride lowering is dose-dependent with the greatest efficacy achieved at the 3.0 mg/kg dose, with triglyceride decreases of ~50%.Animal Model:Male B6/CBF1J mice
Dosage:0 mg/kg, 0.3 mg/kg, 1 mg/kg, 3 mg/kg
Administration:Oral gavage; once daily; for 2 days
Result:Demonstrated a robust and highly significant decrease in circulating plasma triglycerides.
体外研究：
CP-868388 (0-1 mM) displays robust and dose-dependent recruitment of SRC-1 (EC50 of 4.7 nM) and PGC-1α peptide.CP-868388 demonstrate robust and selective transcriptional activation of PPARα with an EC50 of 18 nM in HepG2 cells.
CP-868388 free base is a potent, selective and orally active PPARα agonist with a Ki value of 10.8 nM. CP-868388 free base has little or no affinity for PPARβ (Ki of 3.47 μM) and PPARγ. CP-868388 free base has hypolipidemic and anti-inflammatory actions.
体内研究：
CP-868388 (0-3 mg/kg; oral gavage; once daily; for 2 days; male B6/CBF1J mice) treatment shows a robust and highly significant decrease in circulating plasma triglycerides. Triglyceride lowering is dose-dependent with the greatest efficacy achieved at the 3.0 mg/kg dose, with triglyceride decreases of ~50%.Animal Model:Male B6/CBF1J mice
Dosage:0 mg/kg, 0.3 mg/kg, 1 mg/kg, 3 mg/kg
Administration:Oral gavage; once daily; for 2 days
Result:Demonstrated a robust and highly significant decrease in circulating plasma triglycerides.
体外研究：
CP-868388 (0-1 mM) displays robust and dose-dependent recruitment of SRC-1 (EC50 of 4.7 nM) and PGC-1α peptide.CP-868388 demonstrate robust and selective transcriptional activation of PPARα with an EC50 of 18 nM in HepG2 cells.
产品资料
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