产品
编 号：F431179
分子式：C21H16ClFN2O3S
分子量：430.88
分子式：C21H16ClFN2O3S
分子量：430.88
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
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5mg
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10mg
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50mg
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100mg
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结构图
CAS No: 702662-50-8
产品详情
生物活性：
STING agonist-1 (G10) is human-specific STING agonist that elicits antiviral activity against emerging Alphaviruses. G10 potently blocks replication of Alphavirus species Venezuelan Equine Encephalitis Virus (VEEV) with IC90 of 24.57 μM.
体外研究：
G10 induces IFN/IRF3- but not NF-κB-dependent transcription in human fibroblasts.G10 is an indirect activator of human STING-dependent phenotypes.G10-mediated IRF3 activation and anti-Alphaviral activity occur independently of IPS-1/MAVS-dependent signaling.STING is required for G10-mediated IRF3 activation, gene expression, and anti-Alphaviral activity.G10 induces STING-dependent synthesis and secretion of bioactive interferon.G10 induces innate antiviral mRNA expression in primary human cells.
STING agonist-1 (G10) is human-specific STING agonist that elicits antiviral activity against emerging Alphaviruses. G10 potently blocks replication of Alphavirus species Venezuelan Equine Encephalitis Virus (VEEV) with IC90 of 24.57 μM.
体外研究：
G10 induces IFN/IRF3- but not NF-κB-dependent transcription in human fibroblasts.G10 is an indirect activator of human STING-dependent phenotypes.G10-mediated IRF3 activation and anti-Alphaviral activity occur independently of IPS-1/MAVS-dependent signaling.STING is required for G10-mediated IRF3 activation, gene expression, and anti-Alphaviral activity.G10 induces STING-dependent synthesis and secretion of bioactive interferon.G10 induces innate antiviral mRNA expression in primary human cells.
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