产品
编 号:F431133
分子式:C8H13NO3
分子量:171.19
产品类型
结构图
CAS No: 702-54-5
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产品详情
生物活性:
Dioxone is a substance possessing convulsant properties qualitatively similar to leptazol and bemegride. Dioxone is orally active.
体内研究:
Dioxone (0-30 mg/kg; i.v., i.p., oral, s.c.; once) induces convulsant action.Animal Model:CF-1 Mice and CF-Wistar rats
Dosage:0-30 mg/kg
Administration:Intraperitoneal injection, once
Result:In mice: The spontaneous activity was often reduced, always accompanied by hyperreactivity at 10 mg/kg, tremors, clonic convulsion and motor incoordination phenomena occured after the administration of 30 mg/kg. In rats: Tremors and some isolated clonus of the muscles of the limbs were observed with 10 mg/kg, clonic convukions occurred with doses above 15 mg/kg.
体外研究:
Dioxone is soluble in ethanol, ether, chloroform and propylene glycol. A 1 percent aqueous solution may be obtained at room temperature giving a pH of 4.3, and, with warming to 50℃, 2 percent aqueous solutions may be prepared.