产品
编 号：F430252
分子式：C5H4N4O3
分子量：168.11
分子式：C5H4N4O3
分子量：168.11
产品类型
规格
价格
是否有货
500mg
320
In-stock
1g
400
In-stock
结构图
CAS No: 69-93-2
产品详情
生物活性：
Uric acid, scavenger of oxygen radical, is a very important antioxidant that help maintains the stability of blood pressure and antioxidant stress. Uric acid can remove reactive oxygen species (ROS) such as singlet oxygen and peroxynitrite, inhibiting lipid peroxidation.
体内研究：
Uric acid 可用于动物建模，构建高血压模型。Animal Model:Eight-week-old male C57BL/6J mice
Dosage:250 mg/kg body weight
Administration:P.o.
Result:When mice treated with indomethacin were concurrently administered uric acid orally, ulcer areas were significantly reduced, in a uric acid dose-dependent manner.
体外研究：
Uric acid (400 μM; 48 hours) protects Caco-2 cells from indomethacin-induced lipid peroxidation.?Co-treatment of cells with Indomethacin and Uric acid (200 μM IND plus 400 μM UA; 24 hours) significantly decreases ROS levels compared to those in cells incubated with indomethacin alone. Cell viability in Caco-2 cells treated with both Indomethacin and Uric acid (200 μM IND plus 400 μM UA; 24 hours) is higher than that in cells treated with indomethacin alone. Uric acid has a protective effect on indomethacin-induced intestinal cell changes through its antioxidant activity.
Uric acid, scavenger of oxygen radical, is a very important antioxidant that help maintains the stability of blood pressure and antioxidant stress. Uric acid can remove reactive oxygen species (ROS) such as singlet oxygen and peroxynitrite, inhibiting lipid peroxidation.
体内研究：
Uric acid 可用于动物建模，构建高血压模型。Animal Model:Eight-week-old male C57BL/6J mice
Dosage:250 mg/kg body weight
Administration:P.o.
Result:When mice treated with indomethacin were concurrently administered uric acid orally, ulcer areas were significantly reduced, in a uric acid dose-dependent manner.
体外研究：
Uric acid (400 μM; 48 hours) protects Caco-2 cells from indomethacin-induced lipid peroxidation.?Co-treatment of cells with Indomethacin and Uric acid (200 μM IND plus 400 μM UA; 24 hours) significantly decreases ROS levels compared to those in cells incubated with indomethacin alone. Cell viability in Caco-2 cells treated with both Indomethacin and Uric acid (200 μM IND plus 400 μM UA; 24 hours) is higher than that in cells treated with indomethacin alone. Uric acid has a protective effect on indomethacin-induced intestinal cell changes through its antioxidant activity.
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