产品
编 号：F429468
分子式：C6H14O6
分子量：182.17
分子式：C6H14O6
分子量：182.17
产品类型
规格
价格
是否有货
500mg
320
In-stock
5g
400
In-stock
10g
640
In-stock
结构图
CAS No: 69-65-8
产品详情
生物活性：
D-Mannitol (Mannitol) is an oral, resistant sugar widely used in the food and pharmaceutical industries to promote the absorption and retention of calcium and magnesium through cecal fermentation, while acting as a osmotic diuretic to reduce tissue edema. D-Mannitol can enhance brown fat formation, improve insulin effect, reduce blood sugar levels, And through the start the β3-adrenergic receptor (β3-AR), PGC1α and PKA induced by means of white fat cells into brown fat cells.
体内研究：
D-Mannitol (口服; 7 或 28 天) 在雄性 Wistar 大鼠模型中通过在盲肠中发酵，促进钙和镁的吸收和保留。D-Mannitol (0.5, 2.5, 1.5 g/kg; 静脉注射; 每隔 4 小时一次; 共 24 小时) 在缺血性皮质梗死的大鼠模型中的反复输注，会导致梗死区及同侧半球 H2O 的百分比减少以及组织压力的降低。D-Mannitol (250, 500 mg/kg; 口服; 3 周) 在小鼠模型中通过脂质 β-氧化增加能量消耗，从而有助于体内腹股沟白色脂肪组织 (iWAT)的棕色化。Animal Model:4-wk-old growing male Wistar rats
Dosage:20-80 g/kg
Administration:Oral gavage (p.o.), 28 days
Result:Improved absorption and retention of calcium (Ca) and magnesium (Mg).
Animal Model:9-wk-old growing male Wistar rats
Dosage:40 g/kg, 80 g/kg
Administration:Oral gavage (p.o.), 7 days
Result:Increased cecal weight and tissue weight, and reduced pH.
Animal Model:Adult cats
Dosage: 0.33 gm/kg
Administration:Intraperitoneal injection (i.p.), 4-hour intervals, single dose or five doses
Result:After multiple injections, the osmotic concentration gradient between vasogenic cerebral edema and plasma was reversed, which was associated with the worsening of vasogenic cerebral edema.
Animal Model:Ischemic cortex infarction model in rats
Dosage:0.5, 2.5, 1.5 g/kg
Administration:Intravenous injection (i.v.), 4-hour intervals, 24h
Result:Repeated infusion results in a dose-dependent increase in plasma osmotic pressure and a dose-dependent decrease in the percentage of water in the ischemic cerebral tissue of the arterial cortex and ipsilateral hemisphere.Significantly reduced organizational stress.
Animal Model:Mouse Model
Dosage:250 mg/kg, 500 mg/kg
Administration:Oral gavage (p.o.), 3 weeks
Result:Caused a significant decrease in the average body weight of the mice.Increased the conversion of white adipose tissue to brown tissue.Led to a significant increase in the expression of genes regulating mitochondrial heat production and lipid oxidation, such as Cidea, CPT1, UCP1, and PGC1α.
体外研究：
D-Mannitol (10 μM) 在分化的 3T3-L1 细胞模型中可以增加线粒体的数量并促进棕色脂肪相关基因的表达。D-Mannitol (10 μM; 7 天) 在3T3-L1 脂肪细胞细胞中具有刺激棕色脂肪形成、增强胰岛素效应、降低血糖水平以及促进脂肪氧化和白色脂肪向米色脂肪的转化的作用。D-Mannitol (10 μM; 7 天) 通过激活 β3-肾上腺素能受体 ( β3-AR)， PGC1α 和 PKA 诱导白色脂肪细胞褐变。
D-Mannitol (Mannitol) is an oral, resistant sugar widely used in the food and pharmaceutical industries to promote the absorption and retention of calcium and magnesium through cecal fermentation, while acting as a osmotic diuretic to reduce tissue edema. D-Mannitol can enhance brown fat formation, improve insulin effect, reduce blood sugar levels, And through the start the β3-adrenergic receptor (β3-AR), PGC1α and PKA induced by means of white fat cells into brown fat cells.
体内研究：
D-Mannitol (口服; 7 或 28 天) 在雄性 Wistar 大鼠模型中通过在盲肠中发酵，促进钙和镁的吸收和保留。D-Mannitol (0.5, 2.5, 1.5 g/kg; 静脉注射; 每隔 4 小时一次; 共 24 小时) 在缺血性皮质梗死的大鼠模型中的反复输注，会导致梗死区及同侧半球 H2O 的百分比减少以及组织压力的降低。D-Mannitol (250, 500 mg/kg; 口服; 3 周) 在小鼠模型中通过脂质 β-氧化增加能量消耗，从而有助于体内腹股沟白色脂肪组织 (iWAT)的棕色化。Animal Model:4-wk-old growing male Wistar rats
Dosage:20-80 g/kg
Administration:Oral gavage (p.o.), 28 days
Result:Improved absorption and retention of calcium (Ca) and magnesium (Mg).
Animal Model:9-wk-old growing male Wistar rats
Dosage:40 g/kg, 80 g/kg
Administration:Oral gavage (p.o.), 7 days
Result:Increased cecal weight and tissue weight, and reduced pH.
Animal Model:Adult cats
Dosage: 0.33 gm/kg
Administration:Intraperitoneal injection (i.p.), 4-hour intervals, single dose or five doses
Result:After multiple injections, the osmotic concentration gradient between vasogenic cerebral edema and plasma was reversed, which was associated with the worsening of vasogenic cerebral edema.
Animal Model:Ischemic cortex infarction model in rats
Dosage:0.5, 2.5, 1.5 g/kg
Administration:Intravenous injection (i.v.), 4-hour intervals, 24h
Result:Repeated infusion results in a dose-dependent increase in plasma osmotic pressure and a dose-dependent decrease in the percentage of water in the ischemic cerebral tissue of the arterial cortex and ipsilateral hemisphere.Significantly reduced organizational stress.
Animal Model:Mouse Model
Dosage:250 mg/kg, 500 mg/kg
Administration:Oral gavage (p.o.), 3 weeks
Result:Caused a significant decrease in the average body weight of the mice.Increased the conversion of white adipose tissue to brown tissue.Led to a significant increase in the expression of genes regulating mitochondrial heat production and lipid oxidation, such as Cidea, CPT1, UCP1, and PGC1α.
体外研究：
D-Mannitol (10 μM) 在分化的 3T3-L1 细胞模型中可以增加线粒体的数量并促进棕色脂肪相关基因的表达。D-Mannitol (10 μM; 7 天) 在3T3-L1 脂肪细胞细胞中具有刺激棕色脂肪形成、增强胰岛素效应、降低血糖水平以及促进脂肪氧化和白色脂肪向米色脂肪的转化的作用。D-Mannitol (10 μM; 7 天) 通过激活 β3-肾上腺素能受体 ( β3-AR)， PGC1α 和 PKA 诱导白色脂肪细胞褐变。
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