产品
编 号：F429463
分子式：C8H11N5NaO3
分子量：248.19
分子式：C8H11N5NaO3
分子量：248.19
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CAS No: 69657-51-8
产品详情
生物活性：
Acyclovir (Aciclovir) sodium is a potent, orally active antiviral agent. Acyclovir sodium has antiherpetic activity with IC50 values of 0.85 μM and 0.86 μM for HSV-1 and HSV-2, respectively. Acyclovir sodium induces cell cycle perturbation and apoptosis. Acyclovir sodium prevents bacterial infections during induction therapy for acute leukaemia.
体内研究：
Acyclovir (Aciclovir) sodium (20 mg/kg; p.o.; three times daily; for 10 d; BALB/c mice) suppresses the development of skin lesions and results in a dissociation between DTH response and antibody productionAnimal Model:Specific-pathogen-free BALB/c mice (7-week-old) infected with HSV-1
Dosage:20 mg/kg
Administration:Oral administration; three times daily; for 10 days
Result:Suppressed the development of skin lesions and resulted in a dissociation between DTH response and antibody production.
体外研究：
Acyclovir (Aciclovir) sodium (3-100 μM; 24-72 hours; Jurkat, U937, and K562 leukemia cells) reduces cell viability in a dose- and time-dependent.Acyclovir (Aciclovir) sodium (10-100 μM; 24-72 hours; Jurkat cells) blocks DNA synthesis, thereby arresting the cell cycle in G2/M and S phases and increasing the sub-G1 hypodiploid peak in a dose-dependent manner.Acyclovir (Aciclovir) sodium (10-100 μM; 24-72 hours; Jurkat cells) induces apoptosis through activates caspase-3 and presences nuclear DNA fragmentation.
Acyclovir (Aciclovir) sodium is a potent, orally active antiviral agent. Acyclovir sodium has antiherpetic activity with IC50 values of 0.85 μM and 0.86 μM for HSV-1 and HSV-2, respectively. Acyclovir sodium induces cell cycle perturbation and apoptosis. Acyclovir sodium prevents bacterial infections during induction therapy for acute leukaemia.
体内研究：
Acyclovir (Aciclovir) sodium (20 mg/kg; p.o.; three times daily; for 10 d; BALB/c mice) suppresses the development of skin lesions and results in a dissociation between DTH response and antibody productionAnimal Model:Specific-pathogen-free BALB/c mice (7-week-old) infected with HSV-1
Dosage:20 mg/kg
Administration:Oral administration; three times daily; for 10 days
Result:Suppressed the development of skin lesions and resulted in a dissociation between DTH response and antibody production.
体外研究：
Acyclovir (Aciclovir) sodium (3-100 μM; 24-72 hours; Jurkat, U937, and K562 leukemia cells) reduces cell viability in a dose- and time-dependent.Acyclovir (Aciclovir) sodium (10-100 μM; 24-72 hours; Jurkat cells) blocks DNA synthesis, thereby arresting the cell cycle in G2/M and S phases and increasing the sub-G1 hypodiploid peak in a dose-dependent manner.Acyclovir (Aciclovir) sodium (10-100 μM; 24-72 hours; Jurkat cells) induces apoptosis through activates caspase-3 and presences nuclear DNA fragmentation.
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