产品
编 号：F429444
分子式：C22H24O9
分子量：432.42
分子式：C22H24O9
分子量：432.42
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CAS No: 6965-36-2
产品详情
生物活性：
5'-Methoxynobiletin is a potent and orally active antinociceptive and anti-inflammatory agent. 5'-Methoxynobiletin is a polymethoxyflavone, that can be isolated from A. conyzoides.
体内研究：
5'-Methoxynobiletin (5mg /kg, 腹腔注射) 可显著降低白细胞计数、中性粒细胞流入和渗出液中的蛋白质浓度，并降低几种促炎介质的水平。5'-Methoxynobiletin (100 mg/kg，口服，一次) 显示出抗伤害和抗炎活性。5'-Methoxynobiletin (10 mg/kg，静脉注射；50 mg/kg，口服；一次) 在大鼠体内的口服生物利用度较低，约为 8-11%。Animal Model:Swiss mice (female)
Dosage:100 mg/kg
Administration:Orally
Result:Significantly reduced both phases of formalin-induced nocifensive behavior after 15, 30 and 60 min of oral administration, when compared to control groups. In the neurogenic phase, inhibitions of 43±3%, 68±6% and 53±5% of the nociceptive response were observed, while for the infammatory phase inhibitions were 70±8%, 91±3% and 85±3% after 15, 30 and 60 min of the oral administration of 5'-Methoxynobiletin, respectively.
Animal Model:Wistar rats (male)
Dosage:10 mg/kg (IV), 50 mg/kg (oral)
Administration:IV, oral, once (Pharmacokinetic Analysis)
Result:Pharmacokinetic Parameters of 5'-Methoxynobiletin in male Wistar rats.IV (10 mg/kg) IG (50 mg/kg)
λ (h-1)0.55±0.030.29±0.2
Tmax (h)2.71±0.49
Cmax (mg/L)0.62±0.21
AUC0-∞ (mg·h/L)8.19±4.1 3.65±0.8
t1/2 elimination (h)1.26±0.12.31±0.9
CL (L/h.kg)1.22±0.2613.68±0.29
Vd, ss (L/kg)2.24±0.3247.46±10.10
F (%)8.67
5'-Methoxynobiletin is a potent and orally active antinociceptive and anti-inflammatory agent. 5'-Methoxynobiletin is a polymethoxyflavone, that can be isolated from A. conyzoides.
体内研究：
5'-Methoxynobiletin (5mg /kg, 腹腔注射) 可显著降低白细胞计数、中性粒细胞流入和渗出液中的蛋白质浓度，并降低几种促炎介质的水平。5'-Methoxynobiletin (100 mg/kg，口服，一次) 显示出抗伤害和抗炎活性。5'-Methoxynobiletin (10 mg/kg，静脉注射；50 mg/kg，口服；一次) 在大鼠体内的口服生物利用度较低，约为 8-11%。Animal Model:Swiss mice (female)
Dosage:100 mg/kg
Administration:Orally
Result:Significantly reduced both phases of formalin-induced nocifensive behavior after 15, 30 and 60 min of oral administration, when compared to control groups. In the neurogenic phase, inhibitions of 43±3%, 68±6% and 53±5% of the nociceptive response were observed, while for the infammatory phase inhibitions were 70±8%, 91±3% and 85±3% after 15, 30 and 60 min of the oral administration of 5'-Methoxynobiletin, respectively.
Animal Model:Wistar rats (male)
Dosage:10 mg/kg (IV), 50 mg/kg (oral)
Administration:IV, oral, once (Pharmacokinetic Analysis)
Result:Pharmacokinetic Parameters of 5'-Methoxynobiletin in male Wistar rats.IV (10 mg/kg) IG (50 mg/kg)
λ (h-1)0.55±0.030.29±0.2
Tmax (h)2.71±0.49
Cmax (mg/L)0.62±0.21
AUC0-∞ (mg·h/L)8.19±4.1 3.65±0.8
t1/2 elimination (h)1.26±0.12.31±0.9
CL (L/h.kg)1.22±0.2613.68±0.29
Vd, ss (L/kg)2.24±0.3247.46±10.10
F (%)8.67
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